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2015 new CPT code for SURGICAL PATHOLOGY( MORPHOMETRIC ANALYSIS - IN SITU HYBRIDIZATION)


These new clarified guidelines will require pathologist/laboratories to clearly document when a multiplex/cocktail stained probe procedure has been performed for morphometric analysis by in situ hybridization.

Unit of service for morphometric analysis by in situ hybridization is per specimen, per separate single probe stain procedure.

Use code:
• 88367 or 88368 (semi/quantitative--depending on manual versus computer assisted) for the first single probe stain procedure


• 88373 or 88369 for semi/quantitative---depending on manual or computer assisted for each additional single probe stain procedure.


For multiplex staining procedures: Use 88374 or 88377 (semi/quantitative—depending on manual versus computer assisted) when multiple antibodies on a probe by a single staining procedure.


The terms “single probe stain procedure” and “multiplex probe stain procedure” will play a vital part in the units of service as well as the code(s) that is selected. Using the term single probe stain procedure indicates that the same probe that may contain multiple different antibodies on that probe must be assigned the code associated with multiplex probe stain procedure.


It is the procedure that also determines the unit of service of that multiplex probe stain. If the probe(s) are performed in one single stain procedure, then you must consider that one unit of service for that multiplex probe.

For example, if a morphometric analysis by in situ hybridization is performed with a dual probe containing two different antibodies on that single probe, reported in semi/quantitative value...that is one unit of service of 88374 or 88377 (depending on semi/quantitative--manual versus computer assisted).


CPT Code: +88369
Code Description:
Morphometric analysis, in situ hybridization (quantitative or semi-quantitative), manual,
per specimen; each additional single probe stain procedure (List separately in addition
to code for primary procedure)
Use 88369 in conjunction with 88368


CPT CODE:+88373 
Code Description:
Morphometric analysis, in situ hybridization (quantitative or semi-quantitative), using
computer-assisted technology, per specimen; each additional single probe stain
procedure (List separately in addition to code for primary procedure)
Use 88373 in conjunction with 88367


CPT CODE:88374
Code Description:
Morphometric analysis, in situ hybridization (quantitative or semi-quantitative), using
computer-assisted technology, per specimen; each multiplex probe stain procedure
Do not report 88367, 88374 in conjunction with 88365, 88366, 88368, 88377 for the
same probe 


CPT CODE:88377
Code Description;
Morphometric analysis, in situ hybridization (quantitative or semi-quantitative), manual,
per specimen; each multiplex probe stain procedure
Do not report 88368 or 88377 in conjunction with 88365, 88366, 88367, 88374 for
the same probe 


Reference: www.ama-assn.org/

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