CPT Code         Code Description
80320                Alcohols
80321                Alcohol biomarkers; 1 or 2 
80322                Alcohol biomarkers; 3 or more
80323                Alkaloids, not otherwise specified
80324                Amphetamines; 1 or 2
80325                Amphetamines; 3 or 4 
80326                Amphetamines; 5 or more
80327                Anabolic steroids; 1 or 2
80328                Anabolic steroids; 3 or more
80329                Anagesics, non-opiod; 1 or 2
80330                Analgesics, non-opiod; 3-5
80331                Analgesics, non-opiod; 6 or more
80332                Antidepressants, serotonergic class; 1 or 2
80333                Antidepressants, serotonergic class; 3-5
80334                Antidepressants, serotonergic class; 6 or more
80335                Antidepressants, tricyclic and other cyclical; 1 or 2
80336                Antidepressants, tricyclic and other cyclical; 3-5
80337                Antidepressants, tricyclic and other cyclical; 6 or more
80338                Antidepressants, not otherwise classified
80339                Antiepileptics, not otherwise specified; 1-3
80340                Antiepileptics, not otherwise specified; 4-6
80341                Antiepileptics, not otherwise specified; 7 or more
80342                Antipsychotics, not otherwise specified; 1-3
80343                Antipsychotics, not otherwise specified; 4-6
80344                Antipsychotics, not otherwise specified; 7 or more
80345                Barbiturates
80346                Benzodiazepines; 1-12
80347                Benzodiazepines; 13 or more
80348                Buprenorphine
80349                Cannabinoids, natural  
80350                Cannabinoids, synthetic; 1-3          
80351                Cannabinoids, synthetic; 4-6
80352                Cannabinoids, synthetic; 7 or more
80353                Cocaine
80354                Fentanyl
80355                Gabapentin, non-blood
80356                Heroin metabolite 
80357                Ketamine and norketamine
80358                Methadone
80359                Methylenedioxyamphetamines (MDA, MDEA, MDMA)
80360                Methyphenidate
80361                Opiates, 1 or more
80362                Opiods and opiate analogs; 1 or 2
80363                Opiods and opiate analogs; 3 or 4
80364                Opiods and opiate analogs; 5 or more
80365                Oxycodone
80366                Pregabalin
80367                Propoxyphene
80368                Sedative hypnotics (non-benzodiazepines)
80369                Skeletal muscle relaxants; 1 o 2
80370                Skeletal muscle relaxants; 3 or more
80371                Stimulants, synthetic
80372                Tapentadol
80373                Tramadol
80374                Stereoisomer (enantiomer) analysis, single drug class
80375                Drug(s) or substance(s), definitive, qualitative or quantitative,not  otherwise specified; 1-3
80376                Drug(s) or substance(s), definitive, qualitative or quantitative,not  otherwise specified; 4-6
80377                Drug(s) or substance(s), definitive, qualitative or quantitative,not  otherwise specified; 7 or more

The Definitive Drug Class methods are able to identify individual drugs and distinguish between structural isomers but not necessarily stereoisomers, such as gas chromatography with mass spectrometry, liquid chromatography mass spectrometry. The AMA specifically reminds that methods such as immunoassay or enzymatic methods are EXCLUDED from being considered definitive drug
testing (i.e., they are presumptive).

When chromatography is used, each combination of stationary and mobile phase is to be counted as one procedure. This drug class testing also allows for qualitative as well as quantitative or a combination of qualitative and quantitative values. The Definitive Drug Class Listing provides the drug classes, their associated codes, and the drugs included in each class.

Each category of a drug class, including metabolite(s) if performed (except steroisomers), is reported once per date of service. If a metabolite is not listed in the table, the AMA states to report using the code for the parent drug. Drug class metabolite(s) is not reported separately unless the metabolite(s) is listed as a separate category in the Definitive Drug Classes Listing (e.g., heroin metabolite). Definitive drug procedures that are not specified for the code range 80320-80373 should be reported using the unlisted definitive procedure codes 80375, 80376, 80377, unless the specific analyte is listed in the Therapeutic Drug Assays section (80150-80203) or Chemistry section (82009-84830) sections. In other words, you are not to use the unlisted definitive codes if the drug is listed in either of those sections.

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