CPT Code Code Description
80320 Alcohols
80321 Alcohol biomarkers; 1 or 2
80322 Alcohol biomarkers; 3 or more
80323 Alkaloids, not otherwise specified
80324 Amphetamines; 1 or 2
80325 Amphetamines; 3 or 4
80326 Amphetamines; 5 or more
80327 Anabolic steroids; 1 or 2
80328 Anabolic steroids; 3 or more
80329 Anagesics, non-opiod; 1 or 2
80330 Analgesics, non-opiod; 3-5
80331 Analgesics, non-opiod; 6 or more
80332 Antidepressants, serotonergic class; 1 or 2
80333 Antidepressants, serotonergic class; 3-5
80334 Antidepressants, serotonergic class; 6 or more
80335 Antidepressants, tricyclic and other cyclical; 1 or 2
80336 Antidepressants, tricyclic and other cyclical; 3-5
80337 Antidepressants, tricyclic and other cyclical; 6 or more
80338 Antidepressants, not otherwise classified
80339 Antiepileptics, not otherwise specified; 1-3
80340 Antiepileptics, not otherwise specified; 4-6
80341 Antiepileptics, not otherwise specified; 7 or more
80342 Antipsychotics, not otherwise specified; 1-3
80343 Antipsychotics, not otherwise specified; 4-6
80344 Antipsychotics, not otherwise specified; 7 or more
80345 Barbiturates
80346 Benzodiazepines; 1-12
80347 Benzodiazepines; 13 or more
80348 Buprenorphine
80349 Cannabinoids, natural
80350 Cannabinoids, synthetic; 1-3
80351 Cannabinoids, synthetic; 4-6
80352 Cannabinoids, synthetic; 7 or more
80353 Cocaine
80354 Fentanyl
80355 Gabapentin, non-blood
80356 Heroin metabolite
80357 Ketamine and norketamine
80358 Methadone
80359 Methylenedioxyamphetamines (MDA, MDEA, MDMA)
80360 Methyphenidate
80361 Opiates, 1 or more
80362 Opiods and opiate analogs; 1 or 2
80363 Opiods and opiate analogs; 3 or 4
80364 Opiods and opiate analogs; 5 or more
80365 Oxycodone
80366 Pregabalin
80367 Propoxyphene
80368 Sedative hypnotics (non-benzodiazepines)
80369 Skeletal muscle relaxants; 1 o 2
80370 Skeletal muscle relaxants; 3 or more
80371 Stimulants, synthetic
80372 Tapentadol
80373 Tramadol
80374 Stereoisomer (enantiomer) analysis, single drug class
80375 Drug(s) or substance(s), definitive, qualitative or quantitative,not otherwise specified; 1-3
80376 Drug(s) or substance(s), definitive, qualitative or quantitative,not otherwise specified; 4-6
80377 Drug(s) or substance(s), definitive, qualitative or quantitative,not otherwise specified; 7 or more
The Definitive Drug Class methods are able to identify individual drugs and distinguish between structural isomers but not necessarily stereoisomers, such as gas chromatography with mass spectrometry, liquid chromatography mass spectrometry. The AMA specifically reminds that methods such as immunoassay or enzymatic methods are EXCLUDED from being considered definitive drug
testing (i.e., they are presumptive).
When chromatography is used, each combination of stationary and mobile phase is to be counted as one procedure. This drug class testing also allows for qualitative as well as quantitative or a combination of qualitative and quantitative values. The Definitive Drug Class Listing provides the drug classes, their associated codes, and the drugs included in each class.
Each category of a drug class, including metabolite(s) if performed (except steroisomers), is reported once per date of service. If a metabolite is not listed in the table, the AMA states to report using the code for the parent drug. Drug class metabolite(s) is not reported separately unless the metabolite(s) is listed as a separate category in the Definitive Drug Classes Listing (e.g., heroin metabolite). Definitive drug procedures that are not specified for the code range 80320-80373 should be reported using the unlisted definitive procedure codes 80375, 80376, 80377, unless the specific analyte is listed in the Therapeutic Drug Assays section (80150-80203) or Chemistry section (82009-84830) sections. In other words, you are not to use the unlisted definitive codes if the drug is listed in either of those sections.