Allergic Or Hypersensitivity Conditions – Definitions & ICD 11 Codes


Definition of Allergic Or Hypersensitivity Conditions: Allergy is a hypersensitivity reaction initiated by a proven immunologic mechanisms.

Hypersensitivity is defined as conditions clinically resembling allergy that cause objectively reproducible symptoms or signs, initiated by exposure to a defined stimulus at a dose tolerated by normal subjects.


Coded Elsewhere:

  • Eosinophilia (4B03)
  • Hypersensitivity reactions of unspecified nature (4B07)

Allergic or hypersensitivity disorders involving the respiratory tract

Definition of Allergic or hypersensitivity disorders involving the respiratory tract: Allergic or hypersensitivity disorders involving the respiratory tract includes several clinically different conditions that can be considered as hypersensitivity disorders of the upper and lower respiratory tract. The classification of these conditions is complex.

ICD 11 Code For Allergic or hypersensitivity disorders involving the respiratory tract

  4A80  Allergic or hypersensitivity disorders involving the respiratory tract

Coded Elsewhere:

  • Vasomotor or allergic rhinitis (CA08)
  • Aspergillus-induced allergic or hypersensitivity conditions (CA82.4)
  • Chronic rhinosinusitis (CA0A)
  • Asthma (CA23)
  • Nasal polyp (CA0J)
  • Hypersensitivity pneumonitis due to organic dust (CA70)

4A80.0 Drug-induced bronchospasm

Definition of Drug-induced bronchospasm: Drug-induced bronchospasm is a common clinical manifestation triggered by various drugs. It ranges in severity from mild to severe, and even fatal from post-anoxic brain damage. It can be manifested as an isolated event or in combination with other symptoms as representation of drug-induced anaphylaxis.

4A80.1 Bronchospasm provoked by allergy to food substance

Definition of Bronchospasm provoked by allergy to food substance: Bronchospasm provoked by allergy to food allergens is clinical manifestation triggered by various foods as a phenotype of food hypersensitivity. It is more frequent in the youngest atopic patients and the most common foods responsible for these reactions are cow milk, peanut, egg and tree nuts. This clinical presentation can be manifested as an isolated event or in combination with other symptoms as representation of drug-induced anaphylaxis.

4A80.Y Other specified allergic or hypersensitivity disorders involving the respiratory tract

4A80.Z Allergic or hypersensitivity disorders involving the respiratory tract unspecified

Allergic or hypersensitivity disorders involving the eye

Definition of Allergic or hypersensitivity disorders involving the eye: Allergic or hypersensitivity disorders involving the eye includes several clinically different conditions that can be considered as hypersensitivity disorders of the ocular surface. The classification of these conditions is complex.

ICD 11 Code For Allergic or hypersensitivity disorders involving the eye

  4A81  Allergic or hypersensitivity disorders involving the eye

Coded Elsewhere:

  • Allergic conjunctivitis (9A60.02)
  • Vernal keratoconjunctivitis (9A60.5)
  • Giant papillary conjunctivitis (9A60.00)
  • Irritant contact blepharoconjunctivitis (EK02.11)
  • Acute atopic conjunctivitis (9A60.01)
  • Atopic keratoconjunctivitis (9A60.0Y)
  • Vernal conjunctivitis (9A60.0Y)

Allergic or hypersensitivity disorders involving skin or mucous membranes

Definition of Allergic or hypersensitivity disorders involving skin or mucous membranes: Allergic or hypersensitivity disorders involving the skin and mucous includes a heterogeneous group of disorders involving skin and mucous membranes in which either allergy or hypersensitivity play a part.

ICD 11 Code For Allergic or hypersensitivity disorders involving skin or mucous membranes

  4A82  Allergic or hypersensitivity disorders involving skin or mucous membranes

Coded Elsewhere:

  • Allergic contact dermatitis (EK00)
  • Photo-allergic contact dermatitis (EK01)
  • Allergic contact urticaria (EK10)
  • Protein contact dermatitis (EK11)
  • Allergic contact sensitisation (EK12)
  • Urticaria, angioedema and other urticarial disorders (EB00-EB0Y)
  • Atopic eczema (EA80)
  • Allergy to substances in contact with the skin (EK5Y)

Allergic or hypersensitivity disorders involving the gastrointestinal tract

ICD 11 Code For Allergic or hypersensitivity disorders involving the gastrointestinal tract

  4A83  Allergic or hypersensitivity disorders involving the gastrointestinal tract

Coded Elsewhere:

  • Allergic gastritis (DA42.4)
  • Allergic duodenitis (DA51.3)
  • Allergic or dietetic colitis (DB33.2)
  • Allergic or dietetic enteritis of small intestine (DA94.2)

4A83.0 Food-induced eosinophilic gastroenteritis

Definition of Food-induced eosinophilic gastroenteritis: A disease characterised by eosinophilic infiltration of various layers of stomach and intestine induced by specific food intake in the absence of any known cause of eosinophilia. It can occur in any age and the symptoms vary depending on the site of the intestinal tract involved and degree of eosinophilic inflammation, might include ascites, weight loss, oedema, obstruction.

4A83.1 Food-induced eosinophilic oesophagitis

Definition of Food-induced eosinophilic oesophagitis: A chronic, immune or antigen-mediated oesophageal disease characterised by eosinophilic infiltration of oesophageal wall induced by specific food intake in the absence of any known cause of eosinophilia. The symptoms are related to oesophageal dysfunction, including feeding disorders, reflux symptoms, vomiting, dysphagia, and food impaction.

4A83.Y Other specified allergic or hypersensitivity disorders involving the gastrointestinal tract

4A83.Z Allergic or hypersensitivity disorders involving the gastrointestinal tract unspecified

Anaphylaxis

Definition of Anaphylaxis: Anaphylaxis is a severe, life-threatening systemic hypersensitivity reaction characterised by being rapid in onset with potentially life-threatening airway, breathing, or circulatory problems and is usually, although not always, associated with skin and mucosal changes.

ICD 11 Code For Anaphylaxis

  4A84  Anaphylaxis

4A84.0 Anaphylaxis due to allergic reaction to food

Definition of Anaphylaxis due to allergic reaction to food: Rapidly progressive, multi-system and potentially life-threatening reaction to exposure to a food allergen to which the affected individual has previously been sensitized.

Exclusions:

  • obstruction from food aspiration (ND72)
  • food intolerance (DA96.02)

4A84.1 Drug-induced anaphylaxis

Definition of Drug-induced anaphylaxis: Anaphylaxis attributable to a drug. When severe it may be fatal. This systemic reaction usually develops within minutes to hours of administration of the drug, is often severe and may be fatal. The most frequent drugs causing anaphylaxis are antibiotics, particularly penicillins. Clinically there may be premonitory dizziness or faintness, skin tingling and erythema, followed by urticaria, angio-oedema, bronchospasm, abdominal pain and vasomotor collapse.

Coded Elsewhere:

4A84.2 Anaphylaxis due to insect venom

Definition of Anaphylaxis due to insect venom: Anaphylaxis due to insect venom is a severe systemic hypersensitivity reaction with rapid onset of cutaneous, vascular or respiratory symptoms and signs, either singly or in any combination after exposure (mainly by sting) to an insect venom in a sensitized patient.

Exclusions:

  • Harmful effects of or exposure to noxious substances, Substances chiefly nonmedicinal as to source, Venoms or toxins (NE61)

4A84.3 Anaphylaxis provoked by physical factors

Definition of Anaphylaxis provoked by physical factors: Anaphylaxis provoked by physical factors covers a group of anaphylaxis phenotypes in which physical factors are the main triggers. The most relevant are: exercise-induced anaphylaxis, exercise-induced anaphylaxis dependent on food, cold-induced anaphylaxis.

4A84.30 Exercise-induced anaphylaxis

Definition of Exercise-induced anaphylaxis: Exercise-induced anaphylaxis is disorder in which anaphylaxis occurs after physical activity. The clinical features may include pruritus, urticarial weals, flushing, wheezing, and gastrointestinal disturbance including nausea, abdominal cramping, and diarrhoea. If physical activity continues, angioedema, laryngeal oedema, hypotension, and, ultimately, cardiovascular collapse may occur. Exercise-induced anaphylaxis is most commonly associated with IgE-mediated allergy to food whereby anaphylaxis occurs only if ingestion is followed temporally by exercise. Cessation of physical activity usually results in immediate improvement of symptoms.

4A84.31 Cold-induced anaphylaxis

Definition of Cold-induced anaphylaxis: Cold-induced anaphylaxis is triggered by skin cooling. The deaths are directly caused by the anaphylactic reaction due to drowning when swimming in cold water.

4A84.3Y Anaphylaxis provoked by other specified physical factors

4A84.3Z Anaphylaxis provoked by unspecified physical factors

4A84.4 Anaphylaxis due to inhaled allergens

Definition of Anaphylaxis due to inhaled allergens: Rapid progressive, multisystem life-threatening reaction due to the exposure to a sensitized inhaled allergen, such as particles from rubber gloves or latex products, animal dander and dust mite.

Use additional external cause code, if desired, to identify agent.

Exclusions:

  • Allergic asthma with exacerbation (CA23.00)

4A84.5 Anaphylaxis due to contact with allergens

Definition of Anaphylaxis due to contact with allergens: Anaphylaxis resulting from skin or mucosal contact with a substance or substances capable of inducing IgE-mediated response in patients previously sensitized.

Use additional external cause code, if desired, to identify agent.

4A84.6 Anaphylaxis secondary to mast cell disorder

Definition of Anaphylaxis secondary to mast cell disorder: Symptoms of anaphylaxis secondary to mast cell disorders result from excessive mast cell mediator release, especially histamine, and may include pruritus and flushing, abdominal pain, diarrhea, dyspnoea, tachycardia, or profound hypotension. It happens in both children and adults, but in adults it can occur even without urticaria pigmentosa lesions. Levels of basal tryptase are constantly high. Fatal anaphylaxis has been described following hymenoptera stings and in the preoperative period.

4A84.Y Other specified anaphylaxis

4A84.Z Anaphylaxis unspecified

Complex allergic or hypersensitivity conditions

ICD 11 Code For Complex allergic or hypersensitivity conditions

  4A85  Complex allergic or hypersensitivity conditions

4A85.0 Drug or pharmacological agents hypersensitivity

Definition of Drug or pharmacological agents hypersensitivity: Drug hypersensitivity reactions are the adverse effects of pharmaceutical formulations (including active drugs and excipients) that clinically resemble allergy. It belongs to type B adverse drug reactions, which are defined by the World Health Organization as the dose-independent, unpredictable, noxious, and unintended response to a drug taken at a dose normally used in humans. It covers many different clinical phenotypes with variable onset and severity.

Coded Elsewhere:

  • Drug eruptions (EH60-EH6Z)
  • Drug-induced bronchospasm (4A80.0)
  • Drug-induced aplastic anaemia (3A70.10)
  • Aspirin-induced asthma (CA23.20)
  • Samter syndrome (CA0A.0)
  • Photoallergic drug reaction (EH75)
  • Pseudolymphomatous drug hypersensitivity syndrome (EH6Y)
  • Anaphylaxis due to radiocontrast media (EL80)

4A85.00 Drug-induced liver hypersensitivity disease

Definition of Drug-induced liver hypersensitivity disease: Drug-induced liver hypersensitivity disease is a relatively rare condition, but can have serious consequences for the individual patient, public health, regulatory agencies and the pharmaceutical industry. It is characterised by elevation in serum alanine-aminotransferase (ALT), conjugated bilirubin, or combined bilirubin, ALT and alkaline phosphatase (AP) levels > 2 times the upper limit of normal (ULN) and the most frequent related drugs are halothane, tienilic acid, dihydralazine, diclofenac, and carbamazepine.

4A85.01 Drug-induced kidney hypersensitivity

Definition of Drug-induced kidney hypersensitivity: Drug-induced kidney hypersensitivity constitutes an important cause of acute renal failure and chronic kidney disease in present day clinical practice. Different classes of drugs, by virtue of immunological mechanisms initiate specific inflammatory renal responses, which are manifested by different clinical patterns, such as drug-induced interstitial nephritis. The drug-induced kidney hypersensitivity can manifest alone or in combination with other drug-induced organ or system hypersensitivity disorders.

Coded Elsewhere:

  • Acute renal papillary necrosis due to drugs, biological agents or environmental toxins (GB53)

4A85.02 Drug-induced cytopenia

Definition of Drug-induced cytopenia: Drug-induced cytopenia is a relatively common immune-mediated cytopenia and the target cells include erythrocytes, leukocytes, platelets and hematopoietic precursor cells in the marrow. The most frequent condition is the drug-induced immune thrombocytopenia and the most frequent implicated drugs are penicillin and structurally related drugs, quinine, quinidine, sulfonamide antibiotics, non-steroidal anti-inflammatory drugs and anticonvulsants.

Coded Elsewhere:

  • Drug-induced immune thrombocytopenia (3B64.12)
  • Drug-induced secondary agranulocytosis (4B00.01)

4A85.03 Drug-induced vasculitis

Definition of Drug-induced vasculitis: Drug-induced vasculitis is an inflammatory vasculopathy associated with drugs of almost every class and accounting for approximately 3% of the vasculitides. Although small vessel disease limited to the skin is the most common form, involvement of blood vessels in virtually every organ system may occur. It can present multiorgan involvement and the mortality is described in up to 10% of cases.

4A85.04 Multiple drug hypersensitivity syndrome

Definition of Multiple drug hypersensitivity syndrome: Multiple drug hypersensitivity syndrome is defined as drug allergies to two or more chemically different drugs. It differs from cross-reactivity (due to structural similarities, common metabolic pathways, or pharmacological mechanisms), flare- up reactions (exacerbation of an existing drug allergy by the early switch of therapy to a novel drug), and multiple drug intolerance syndrome.

4A85.0Y Drug hypersensitivity of other specified type

4A85.0Z Drug hypersensitivity of unspecified type

4A85.1 Hypersensitivity to herbal and alternative medical therapies

Definition of Hypersensitivity to herbal and alternative medical therapies: Hypersensitivity to herbal and alternative medical therapies refers to unpredictable conditions clinically resembling allergy that cause objectively reproducible symptoms or signs, initiated by exposure to herbal and other alternatives medical therapies, such as homeopathy, cupping or acupuncture. Herbal and alternative medical therapies are not customarily regarded as drugs, but can trigger immune and non-immune mediated reactions, which occur in susceptible individuals. These reactions are triggered by doses and procedures usually tolerated by normal subjects.

Exclusions:

  • Adverse cutaneous reactions to herbal, homoeopathic or other alternative therapies (EH78)

4A85.2 Food hypersensitivity

Definition of Food hypersensitivity: Food hypersensitivity reactions are adverse effects of food or food additives that clinically resemble allergy. Food allergy is an adverse reaction to food mediated by an immunologic mechanism, involving specific IgE (IgE-mediated), cell-mediated mechanisms (non-IgE-mediated) or both IgE- and cell-mediated mechanisms (mixed IgE- and non-IgE-mediated).

Exclusions:

  • food intolerance (DA96.02)

Coded Elsewhere:

  • Oral allergy syndrome (EK10.0)
  • Contact urticaria due to food allergen (EK10.1)
  • Anaphylaxis due to allergic reaction to food (4A84.0)
  • Bronchospasm provoked by allergy to food substance (4A80.1)

4A85.20 Food-induced gastrointestinal hypersensitivity

Definition of Food-induced gastrointestinal hypersensitivity: Food-induced gastrointestinal hypersensitivity covers a group of gastrointestinal hypersensitivity disorders due to food allergens with variable onset, severity, clinical presentation and mechanisms.

Coded Elsewhere:

  • Food-induced eosinophilic gastroenteritis (4A83.0)
  • Allergic or dietetic colitis (DB33.2)
  • Food-induced eosinophilic oesophagitis (4A83.1)
  • Allergic or dietetic enteritis of small intestine (DA94.2)
  • Food-induced non-IgE-mediated gastrointestinal hypersensitivity (DA42.41)

4A85.21 Food-induced urticaria or angioedema

Definition of Food-induced urticaria or angioedema: Urticaria and/or angioedema triggered by ingestion or direct contact of food allergen in sensitized patient.

4A85.22 Allergic contact dermatitis due to food allergen

Definition of Allergic contact dermatitis due to food allergen: Allergic contact dermatitis, which most common causal foods are spices, fruits, vegetables. Often occupational because of contact with chemical moieties, oleoresins. Systemic contact dermatitis is a rare variant because of ingestion.

Use additional external cause code, if desired, to identify agent.

Coded Elsewhere:

  • Allergic contact dermatitis due to food flavours or additives (EK00.3)

4A85.2Y Other specified food hypersensitivity

4A85.2Z Food hypersensitivity unspecified

4A85.3 Allergic or hypersensitivity reactions to arthropods

Definition of Allergic or hypersensitivity reactions to arthropods: This includes both local cutaneous and systemic allergic and hypersensitivity reactions to contact with insects (e.g. bees, wasps and fire ants) and other arthropods (e.g. scorpions and spiders). Reactions are usually mediated via the immune system (IgE-mediated or non-IgE-mediated allergy).

4A85.30 Systemic allergic reaction due to Hymenoptera venom

Definition of Systemic allergic reaction due to Hymenoptera venom: Systemic Allergic Reaction due to Hymenoptera venom due to insect venom is a severe hypersensitivity reaction with rapid onset of cutaneous, vascular or respiratory symptoms and signs, either singly or in any combination after exposure (mainly by sting) to an insect venom in a sensitized patient.

Coded Elsewhere:

4A85.31 Cutaneous allergic or hypersensitivity reactions to Hymenoptera venom

Definition of Cutaneous allergic or hypersensitivity reactions to Hymenoptera venom: Cutaneous reactions to Hymenoptera venom are hypersensitivity reactions classified into normal local reactions and large local reactions. Large local reaction is defined as a swelling exceeding a diameter of 10 cm which lasts longer than 24 h; blisters may rarely be present.

4A85.32 Cutaneous allergic or hypersensitivity reactions to arthropods

4A85.Y Other specified complex allergic or hypersensitivity conditions

4A85.Z Complex allergic or hypersensitivity conditions unspecified

Allergic or hypersensitivity conditions of other specified type

ICD 11 Code For Allergic or hypersensitivity conditions of other specified type

  4A8Y  Allergic or hypersensitivity conditions of other specified type

Allergic or hypersensitivity conditions of unspecified type

ICD 11 Code For Allergic or hypersensitivity conditions of unspecified type

  4A8Z  Allergic or hypersensitivity conditions of unspecified type

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