CPT Code 0048U | Description & Clinical Information

CPT 0048U describes a unique lab test under the Proprietary Laboratory Analyses (PLA) code, specifically the MSK-IMPACT™ (Integrated Mutation Profiling of Actionable Cancer Targets) from Memorial Sloan Kettering Cancer Center, which is a targeted DNA-sequencing panel for somatic mutations in formalin-fixed paraffin-embedded tumor tissues of solid organ tumors.

Official Description

The CPT book defines CPT code 0048U as: “Oncology (solid organ neoplasia), DNA, targeted sequencing of protein-coding exons of 468 cancer-associated genes, including interrogation for somatic mutations and microsatellite instability, matched with normal specimens, utilizing formalin-fixed paraffin-embedded tumor tissue, report of clinically significant mutation(s)”.

Clinical Information

The procedure described by CPT code 0048U involves carrying out qualitative in vitro laboratory tests using advanced next generation sequencing (NGS) techniques. These tests are performed by lab analysts who analyze formalin-fixed paraffin-embedded tissue of solid organ tumors matched against normal specimens. The aim of these tests is to identify somatic mutations and other genetic abnormalities present in 468 cancer-associated genes.

The lab analysts are also responsible for reporting clinically significant mutations that may guide targeted treatment. Furthermore, the tests performed also help in assessing microsatellite instability, which is a genetic condition that results from an impaired DNA mismatch repair system.

Clinicians often order these tests for patients with solid organ tumors to help guide the selection of appropriate targeted therapies. The results of the tests provide an invaluable resource to clinicians, aiding them in diagnosing and treating cancer patients.

The procedure is highly specialized, requiring advanced laboratory techniques and a team of highly skilled analysts. The analysis of the genetic material is a complex process that involves careful selection and testing of the tumor samples to ensure that accurate results are obtained. The lab analysts must also ensure that the data generated is precise, and that the results are reported in a clear and concise manner.

The importance of this procedure cannot be overstated, as it provides clinicians with the tools needed to make informed decisions when diagnosing and treating cancer patients. The analysis of the genetic material provides insights into the specific mutations present in the tumor, enabling clinicians to tailor their treatment strategies accordingly.

Overall, the procedure described by CPT code 0048U is an integral part of modern cancer diagnosis and treatment. It is a highly specialized procedure that requires extensive training, expertise, and equipment. Nonetheless, it provides an invaluable resource to clinicians and their patients, and has revolutionized the field of cancer diagnosis and treatment.

Return to all the CPT codes for proprietary laboratory analyses.

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