CPT 64450, 64450, cpt code 64450, 64450 cpt code

CPT 64450 | Injection | Anesthetic/Steroid | Other Peripheral Nerve/Branch

CPT code 64450 covers an anesthetic agent(s) and/or steroid injection to a peripheral nerve or branch and can be used if no more specific code is available. 

What Is CPT Code 64450?

CPT code 64450 describes injecting an anesthetic agent and/or steroid close to the peripheral nerve or branch.

The 64450 procedure is typically performed to relieve pain or desensitize an area before surgery or for diagnostic purposes.

The anesthetic agent is used to numb the area, and the steroid can reduce inflammation and swelling. The procedure is performed with a needle and syringe.

CPT code 64450 is used when the provider performs one or more injections during a single procedure.


The CPT book describes CPT code 64450 as: “Injection(s), anesthetic agent(s) and/or steroid; other peripheral nerve or branch.”


The patient is appropriately prepped before the procedure, including cleaning the area where the injection will be given and possibly applying a numbing cream to minimize discomfort.

The provider then uses a needle and syringe to administer one or more injections of an anesthetic agent, steroid, or both near the peripheral nerve or branch.

This anesthetizes the area supplied by the nerve, effectively relieving pain or desensitizing the area to be operated on.

The provider can perform this procedure to determine the cause of pain, nerve irritation, or other diagnostic purposes.

Once the injections have been administered, the provider withdraws the needle and applies a bandage to the site to prevent bleeding or infection.

It’s worth noting that nerve blocks are commonly used to relieve pain and discomfort during surgical procedures and other medical treatments.

They can be used on different body parts, including the head and face, neck, upper and lower extremities, and trunk.

The type of anesthetic and the specific nerve being blocked will depend on the indication for the procedure, and the provider will choose the most appropriate option based on the patient’s needs.

How To Use CPT 64450

CPT code 64450 is a unilateral service and can be billed without a modifier if the procedure is performed on one side of the body.

Suppose the procedure is done on both sides. In that case, you can either report 64450 once with modifier 50 or report it twice, once with modifier RT and again with modifier LT, depending on the payer’s preference.

However, if the provider injects an anesthetic agent or steroid into the plantar common digital nerve, such as in Morton’s neuroma, use CPT 64455 instead.

For injection, anesthetic agent, nerves innervating the sacroiliac joint, use CPT 64451 instead.

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