CPT Code 82105 | Description & Clinical Information
CPT 82105 describes the process of quantitatively measuring the level of alpha-fetoprotein, a glycoprotein that is produced during early fetal development and can also be produced by various tumors later in life.
Official Description
The CPT book defines CPT code 82105 as: “Alpha-fetoprotein (AFP); serum”.
Clinical Information
The procedure described by CPT code 82105 involves measuring the level of alphafetoprotein (AFP) in serum using the immunoassay method. This method uses an antigen-antibody reaction to quantify the amount of AFP present in the sample. The testing is commonly ordered for maternal screening for certain fetal abnormalities.
In addition to fetal screening, providers may also use the testing to determine the presence of embryonal carcinomas, hepatocellular disease, and other malignancies later in life. This demonstrates the diverse applications that the 82105 procedure has in the medical field.
It’s important to note that AFP has a few different names, including fetal alpha globulin, and its typical specimen is serum. For cases where a quantitative amniotic fluid AFP test is needed, code 82106 is available. Qualitative cervicovaginal fluid AFP testing is listed in code 84112, which also includes other cervicovaginal fluid constituents.
It’s crucial to select the correct code based on the source of the specimen submitted for testing and whether the test is qualitative or quantitative. Failure to do so could lead to inaccurate results and potential misdiagnosis.
In summary, the 82105 procedure is an immunoassay method used to measure AFP levels in serum. Its primary use is for maternal screening of fetal abnormalities, but it also has applications in diagnosing certain malignancies. It’s important to select the correct code and specimen type to ensure accurate results.
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