How To Use CPT Code 81383

CPT 81383 describes the high resolution typing of HLA Class II alleles or allele groups. This article will cover the description, procedure, qualifying circumstances, appropriate usage, documentation requirements, billing guidelines, historical information, similar codes and billing examples.

1. What is CPT Code 81383?

CPT 81383 can be used to identify specific alleles for HLA Class II genes. This test involves high resolution typing, which means looking for well-documented alleles and identifying them to a high level of specificity, such as a 4-digit HLA name. It is commonly ordered by clinicians to identify an HLA Class II allele or allele group associated with a specific disease state.

2. Official Description

The official description of CPT code 81383 is: ‘HLA Class II typing, high resolution (ie, alleles or allele groups); one allele or allele group (eg, HLA-DQB1*06:02P), each.’ This code is used to identify specific alleles for HLA Class II genes.

3. Procedure

  1. The lab analyst performs the technical steps for high resolution typing of HLA Class II alleles or allele groups.
  2. This involves extracting nucleic acids, such as DNA or RNA, from the patient’s sample.
  3. The lab analyst then identifies the target HLA Class II antigen equivalent using methods like amplification and hybridization with nucleic acid probes or direct sequencing-based typing.
  4. The test aims to identify specific alleles or allele groups associated with certain conditions.
  5. For rare, non-CWD alleles, the test may involve reporting a string of alleles or a National Bone Marrow Donor Program code instead of a 4-digit HLA name.

4. Qualifying circumstances

CPT 81383 is used when testing for the presence or absence of one HLA Class II allele or allele group. It is typically ordered to identify alleles associated with specific conditions. The test is performed by a lab analyst who follows the technical steps to extract nucleic acids and identify the target HLA Class II antigen equivalent.

5. When to use CPT code 81383

CPT code 81383 should be used when there is a need to identify specific alleles for HLA Class II genes. It is commonly ordered by clinicians to determine the presence or absence of alleles associated with certain conditions. This code is used for high resolution typing, which aims to identify alleles to a high level of specificity.

6. Documentation requirements

To support a claim for CPT 81383, documentation should include:

  • Reason for ordering the test and the specific condition being investigated
  • Details of the technical steps performed by the lab analyst
  • Results of the high resolution typing, including the specific alleles or allele groups identified
  • Signature of the lab analyst who performed the test

7. Billing guidelines

When billing for CPT 81383, ensure that the test is performed to identify one HLA Class II allele or allele group. It is important to follow the specific guidelines provided by payers regarding the reporting of this code. Additionally, if the ordering clinician requests physician interpretation of the test and the pathologist provides an interpretation and writes a report, an additional code may be reported with modifier 26.

8. Historical information

CPT 81383 was added to the Current Procedural Terminology system on January 1, 2012. There have been no updates to the code since its addition.

9. Examples

  1. A patient is suspected to have narcolepsy, and the clinician orders CPT 81383 to identify the presence of the HLA-DQB1*06:02P allele associated with this condition.
  2. A patient with rheumatoid arthritis undergoes HLA Class II typing using CPT 81383 to determine the presence of specific alleles associated with the disease.
  3. A clinician orders CPT 81383 to identify HLA Class II alleles in a patient with celiac disease to aid in diagnosis and treatment planning.
  4. A patient with ankylosing spondylitis undergoes HLA Class II typing using CPT 81383 to identify specific alleles associated with the condition.
  5. CPT 81383 is used to identify HLA Class II alleles in a patient with multiple sclerosis to help determine the risk and prognosis of the disease.
  6. A clinician orders CPT 81383 to identify specific HLA Class II alleles in a patient with systemic lupus erythematosus to aid in diagnosis and treatment decisions.
  7. A patient with psoriasis undergoes HLA Class II typing using CPT 81383 to determine the presence of specific alleles associated with the condition.
  8. CPT 81383 is used to identify HLA Class II alleles in a patient with type 1 diabetes to help determine the risk and management of the disease.
  9. A clinician orders CPT 81383 to identify specific HLA Class II alleles in a patient with inflammatory bowel disease to aid in diagnosis and treatment planning.
  10. A patient with autoimmune hepatitis undergoes HLA Class II typing using CPT 81383 to determine the presence of specific alleles associated with the condition.

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