Disorders Of The Pituitary Hormone System – Definitions & ICD 11 Codes

Definition of Disorders Of The Pituitary Hormone System: Clinical status with increased, decreased, or dysregulated secretion of pituitary hormones, which is caused by a variety of tumourous, non-tumourous, and genetic disorders.

Hyperfunction of pituitary gland

Definition of Hyperfunction of pituitary gland: A disease characterised by hypersecretion of adenohypophyseal hormones such as growth hormone, pralactin, thyrotopin, luteinising hormone, follicle stimulating hormone or adrenocorticotropic hormone.

Clinical status with excessive production of one or more pituitary hormones, which is mostly caused by hormone-producing pituitary adenomas.

ICD 11 Code For Hyperfunction of pituitary gland

  5A60  Hyperfunction of pituitary gland

Exclusions:

  • Nelson syndrome (5A70.3)
  • overproduction of pituitary ACTH (5A70.0)
  • overproduction of thyroid-stimulating hormone (5A02)
  • Cushing syndrome (5A70)
  • Multiple endocrine neoplasia type 1 (2F7A.0)
  • Multiple endocrine neoplasia type 4 (2F7A.0)

5A60.0 Acromegaly or pituitary gigantism

Definition of Acromegaly or pituitary gigantism: Acromegaly is an acquired disorder related to excessive production of growth hormone (GH) and characterised by progressive somatic disfigurement (mainly involving the face and extremities) and systemic manifestations. The main clinical features are broadened extremities (hands and feet), widened thickened and stubby fingers, and thickened soft tissue. The disease also has rheumatologic, cardiovascular, respiratory and metabolic consequences which determine its prognosis. In the majority of cases, acromegaly is related to a pituitary adenoma, either purely GH-secreting (60%) or mixed. Transsphenoidal surgery is often the first-line treatment. When surgery fails to correct GH/IGF-I hypersecretion, medical treatment with somatostatin analogs and/or radiotherapy can be used.

Inclusions:

  • Overproduction of growth hormone

Exclusions:

  • constitutional gigantism (5B12)
  • increased secretion from endocrine pancreas of growth hormone-releasing hormone
  • Constitutional tall stature (5B12)

5A60.1 Hyperprolactinaemia

Definition of Hyperprolactinaemia: Increased peripheral blood levels of prolactin often associated with galactorrhea, sometimes associated with normal ovarian function, but often resulting in a spectrum of ovulatory dysfunction varying between short luteal phase (inadequate preovulatory follicular development), anovulatory cycles, amenorrhea and hypogonadotropic hypogonadism

Coded Elsewhere:

  • Prolactinoma of pituitary gland (2F37.Y)

5A60.2 Syndrome of inappropriate secretion of antidiuretic hormone

Definition of Syndrome of inappropriate secretion of antidiuretic hormone: Syndrome of inappropriate antidiuretic hormone (ADH) secretion (SIADH) is characterised by continued ADH secretion, leading to hyponatremia, hypoosmolality and natriuresis. Exact prevalence is unknown. The disease has been described in all age groups. SIADH is often associated with tumours, pulmonary disease, central nervous system disorders or exposure to drugs. Occasionally, it is found in patients with adrenal, thyroid or pituitary insufficiency. The disorder is caused by gain-of-function mutations in the gene encoding the vasopressin V2 receptor. Fluid restriction is the most common treatment. The outcome is related to the underlying and associated disorders.

5A60.20 Nephrogenic syndrome of inappropriate antidiuresis

5A60.2Y Other specified syndrome of inappropriate secretion of antidiuretic hormone

5A60.2Z Syndrome of inappropriate secretion of antidiuretic hormone unspecified

5A60.3 Central precocious puberty

Definition of Central precocious puberty: Central precocious puberty is defined as the onset of pubertal changes before 8 years of age in girls and before 9.5 years of age in boys due to the overproduction of gonadotropin-releasing hormone (GnRH) by the hypothalamus. It may be idiopathic with no apparent cause (90% of cases in girls, 50% of cases in boys) or secondary to a lesion (tumour or malformation) in the hypothalamus. Other causes may include traumatic brain injury, or genetic disorders, affecting behavioural and psychological development, and final body height.

5A60.Y Other specified hyperfunction of pituitary gland

5A60.Z Hyperfunction of pituitary gland unspecified

Definition of Hyperfunction of pituitary gland unspecified: Clinical status with disordered function of the pituitary gland without excessive pituitary hormone production, which is caused by a variety of diseases

Hypofunction or certain specified disorders of pituitary gland

ICD 11 Code For Hypofunction or certain specified disorders of pituitary gland

  5A61  Hypofunction or certain specified disorders of pituitary gland

Exclusions:

Coded Elsewhere:

5A61.0 Hypopituitarism

Definition of Hypopituitarism: A disorder manifesting a deficiency or decrease of one or more pituitary hormones, which is caused by a variety of diseases such as tumour, trauma/surgery, irradiation, inflammation and haemorrhage/infarction.

Inclusions:

  • pituitary cachexia
  • pituitary short stature

Coded Elsewhere:

  • Prader-Willi syndrome (LD90.3)
  • Argonz-del Castillo Syndrome (5A60.1)

5A61.1 Adrenocorticotropic hormone deficiency

Definition of Adrenocorticotropic hormone deficiency: Deficiency of adrenocorticotropic hormone (ACTH) resulting in functional hypocortisolism. Includes deficiency of corticotropin releasing hormone (CRH, CRF).

5A61.2 Gonadotropin deficiency

Definition of Gonadotropin deficiency: Deficiency of Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH) resulting in hypogonadism (male and female). Includes deficiency of Gonadotropin Releasing Hormone (GnRH, LHRH).

Exclusions:

5A61.3 Growth hormone deficiency

Definition of Growth hormone deficiency: Deficiency of growth hormone in children, adolescents and adults. Includes deficiency of growth hormone releasing hormone (GHRH) and excess of central somatostatin, leading to growth hormone deficiency. Includes idiopathic, inborn and acquired forms of growth hormone deficiency.

Exclusions:

  • Hypopituitarism (5A61.0)

5A61.4 Thyroid stimulating hormone deficiency

Definition of Thyroid stimulating hormone deficiency: Deficiency of thyroid stimulating hormone (TSH), leading to secondary (pituitary) or tertiary (hypothalamic) hypothyroidism Includes deficiency of TSH releasing hormone (TRH).

5A61.40 Acquired central hypothyroidism

Definition of Acquired central hypothyroidism: Central Hypothyroidism is a condition where the thyroid gland produces too little or no thyroid hormone, induced by dysfunction of either hypothalamus or pituitary.

5A61.41 Congenital central hypothyroidism

5A61.4Y Other specified thyroid stimulating hormone deficiency

5A61.4Z Thyroid stimulating hormone deficiency unspecified

5A61.5 Central diabetes insipidus

Definition of Central diabetes insipidus: Central diabetes insipidus (CDI) is a hypothalamus-pituitary disease characterised by polyuria and polydipsia due to a vasopressin (AVP) deficiency. The condition may be associated with deficient secretion of antidiuretic hormone (ADH) and is most frequently idiopathic (possibly due to autoimmune injury to the ADH-producing cells), or may be induced by trauma, pituitary surgery, or hypoxic or ischaemic encephalopathy.

Inclusions:

  • ADH – [antidiuretic hormone secretion] deficiency

Exclusions:

  • Nephrogenic diabetes insipidus (GB90.4A)

5A61.6 Oxytocin deficiency

Definition of Oxytocin deficiency: Isolated oxytocin deficiency or oxytocin deficiency in combination with anterior and/or posterior pituitary deficiencies.

5A61.Y Other specified hypofunction or disorders of pituitary gland

Disorders of the pituitary hormone system unspecified

ICD 11 Code For Disorders of the pituitary hormone system unspecified

  5A6Z  Disorders of the pituitary hormone system unspecified

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