2E60, 2E61, 2E62, 2E63, 2E64, 2E65, 2E66, 2E67, 2E68, 2E69, 2E6A, 2E6B, 2E6Y, 2E6Z

In Situ Neoplasms Except Lymphoid Haematopoietic – ICD 11 Codes

Carcinoma in situ of oral cavity oesophagus or stomach

ICD 11 Code For Carcinoma in situ of oral cavity oesophagus or stomach

2E60  Carcinoma in situ of oral cavity oesophagus or stomach

Exclusions:

  • Melanoma in situ neoplasms (2E63)

2E60.0 Carcinoma in situ of lip oral cavity or pharynx

Exclusions:

  • Carcinoma in situ of aryepiglottic fold, laryngeal aspect (2E62.0)
  • Carcinoma in situ of epiglottis nos (2E62.0)
  • Carcinoma in situ of epiglottis, suprahyoid portion (2E62.0)
  • Carcinoma in situ of skin of lip (2E64)

2E60.1 Carcinoma in situ of oesophagus

Definition of Carcinoma in situ of oesophagus: Stage 0 includes: For squamous cell carcinoma: Tis (HGD), N0, M0, G1, GX, tumour location: Any. For adenocarcinoma: Tis (HGD), N0, M0, G1, GX. Tis: High-grade dysplasia. N0: No regional lymph node metastasis. M0: No distant metastasis. G1: Well differentiated. GX: Grade cannot be assessed-stage grouping as G1. tumour location: Location of the primary cancer site is defined by the position of the upper (proximal) edge of the tumour in the esophagus.

2E60.2 Carcinoma in situ of stomach

Definition of Carcinoma in situ of stomach: Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ: intraepithelial tumour without invasion of the lamina propria. N0: No regional lymph node metastasis. M0: No distant metastasis.

Carcinoma in situ of other or unspecified digestive organs

ICD 11 Code For Carcinoma in situ of other or unspecified digestive organs

  2E61  Carcinoma in situ of other or unspecified digestive organs

Exclusions:

  • Melanoma in situ neoplasms (2E63)

2E61.0 Carcinoma in situ of colon

Definition of Carcinoma in situ of colon: Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ: intraepithelial or invasion of lamina propria. N0: No regional lymph node metastasis. M0: No distant metastasis.

2E61.1 Carcinoma in situ of rectum

Definition of Carcinoma in situ of rectum: Malignant epithelial tumour of rectum that has not invaded adjacent tissue of the large intestine.

2E61.2 Carcinoma in situ of anal canal

Definition of Carcinoma in situ of anal canal: Malignant epithelial tumour that has not invaded beyond the epithelium of the anal canal.

Exclusions:

  • Carcinoma in situ of anal margin (2E64.2)
  • Carcinoma in situ of anal skin (2E64)
  • Carcinoma in situ of perianal skin (2E64.2)

2E61.3 Carcinoma in situ of gallbladder biliary tract or ampulla of Vater

Definition of Carcinoma in situ of gallbladder biliary tract or ampulla of Vater: an early form of cancer without invasion of tumour cells into the surrounding tissue, usually before penetration through the basement membrane.

2E61.Y Carcinoma in situ of other specified digestive organs

2E61.Z Carcinoma in situ of unspecified digestive organs

Carcinoma in situ of middle ear or respiratory system

ICD 11 Code For Carcinoma in situ of middle ear or respiratory system

  2E62  Carcinoma in situ of middle ear or respiratory system

Exclusions:

  • Melanoma in situ neoplasms (2E63)

2E62.0 Carcinoma in situ of larynx

Exclusions:

  • Carcinoma in situ of aryepiglottic fold, hypopharyngeal aspect (2E60.0)
  • Carcinoma in situ of aryepiglottic fold, marginal zone (2E60.0)
  • Carcinoma in situ of aryepiglottic fold, NOS (2E60.0)

2E62.1 Carcinoma in situ of trachea

2E62.2 Carcinoma in situ of bronchus or lung

2E62.Y Carcinoma in situ of other specified sites of middle ear and respiratory system

2E62.Z Carcinoma in situ of unspecified sites of middle ear and respiratory system

Melanoma in situ neoplasms

Definition of Melanoma in situ neoplasms: Stage 0 includes: Tis, N0, M0. Tis: Melanoma in situ. N0: No regional lymph node metastases. M0: No detectable evidence of distant metastases.

ICD 11 Code For Melanoma in situ neoplasms

  2E63  Melanoma in situ neoplasms

2E63.0 Melanoma in situ of skin

Definition of Melanoma in situ of skin: Malignant melanoma confined to the epidermis and described as being in radial growth phase.

2E63.00 Lentigo maligna

Definition of Lentigo maligna: An atypical proliferation of atypical melanocytes in the dermal-epidermal junction, without infiltration of the papillary or reticular dermis. The melanocytic proliferation is associated with actinic damage and epidermal atrophy. It usually occurs in the sun-exposed skin of elderly people. It is a form of melanoma in situ and in approximately 5% of cases it progresses to lentigo maligna melanoma.

2E63.0Z Melanoma in situ of skin unspecified

2E63.1 Melanoma in situ of conjunctiva

2E63.Y Other specified melanoma in situ neoplasms

2E63.Z Melanoma in situ neoplasms unspecified

Carcinoma in situ of skin

Definition of Carcinoma in situ of skin: Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No clinical or radiographic evidence of distant metastasis.

ICD 11 Code For Carcinoma in situ of skin

  2E64  Carcinoma in situ of skin

Exclusions:

  • Melanoma in situ neoplasms (2E63)

Coded Elsewhere:

  • Carcinoma in situ of vulva (2E67.1)
  • Carcinoma in situ of penis (2E67.4)

2E64.0 Intraepidermal squamous cell carcinoma

Definition of Intraepidermal squamous cell carcinoma: Malignant squamous neoplasia confined to the epidermis of extragenital skin and known commonly as Bowen disease. It arises most frequently on chronically sun-exposed glabrous skin of the head and neck or lower legs. It typically presents as single or multiple well-demarcated scaly erythematous patches, nodules or plaques which histologically show extensive keratinocytic atypia. It may develop from preexisting actinic keratosis (Actinic intraepidermal squamous cell carcinoma). Although it is most commonly associated with exposure to ultraviolet radiation, other carcinogens such as arsenic and tar may be implicated. Human papilloma virus may represent an additional risk factor in immunosuppressed patients.

2E64.00 Bowen disease of skin

Definition of Bowen disease of skin: Intraepidermal squamous cell carcinoma due to predisposing factors including chronic human papilloma virus infection, arsenic ingestion, ionising radtiation and chronic immunosuppression.

2E64.01 Actinic intraepidermal squamous cell carcinoma

Definition of Actinic intraepidermal squamous cell carcinoma: Intraepidermal squamous cell carcinoma attributable to chronic exposure to ultraviolet radiation and typically developing from a pre-existing actinic keratosis

2E64.0Y Other specified intraepidermal squamous cell carcinoma

2E64.0Z Intraepidermal squamous cell carcinoma unspecified

2E64.1 Extramammary Paget disease of skin

Definition of Extramammary Paget disease of skin: An intraepithelial adenocarcinoma of apocrine gland-bearing skin and mucous membrane. Clinically it presents as sharply demarcated erythematous plaques most commonly affecting the vulva in women and perianal skin in men.

Coded Elsewhere:

  • Vulvar Paget disease (2E67.11)

2E64.2 Carcinoma in situ of anal margin or perianal skin

Definition of Carcinoma in situ of anal margin or perianal skin: Carcinoma in situ of anal margin or perianal skin is most commonly squamous and related to oncogenic HPV strains, HIV infection or both. It may present as warty pigmented patches (Bowenoid papulosis).

2E64.Y Other specified carcinoma in situ of skin

2E64.Z Carcinoma in situ of skin unspecified

Carcinoma in situ of breast

ICD 11 Code For Carcinoma in situ of breast

  2E65  Carcinoma in situ of breast

Exclusions:

  • carcinoma in situ of skin of breast (2E64)
  • melanoma in situ of breast (skin) (2E63)

2E65.0 Lobular carcinoma in situ of breast

2E65.1 Lobular carcinoma in situ of breast pleomorphic subtype

2E65.2 Ductal carcinoma in situ of breast

Exclusions:

  • Atypical ductal hyperplasia of breast (2F75)

2E65.3 Ductal carcinoma in situ of breast comedo subtype

2E65.4 Mixed ductal and lobular carcinoma in situ of breast

Definition of Mixed ductal and lobular carcinoma in situ of breast: The co-existence of ductal and lobular carcinoma in situ in the breast, without evidence of stromal invasion.

2E65.5 Paget disease of nipple

Definition of Paget disease of nipple: Paget disease of the nipple describes a rare presentation of breast cancer, seen most frequently in women aged 50-60, manifesting with nipple drainage and itching, erythema, crusty, excoriated nipple, thickened plaques and hyperpigmentation (less frequently). It is due to tumour cells invading the nipple-areola complex and represents 1%-3% of all new breast cancer diagnoses.

2E65.Y Other specified carcinoma in situ of breast

2E65.Z Carcinoma in situ of breast unspecified

Carcinoma in situ of cervix uteri

ICD 11 Code For Carcinoma in situ of cervix uteri

  2E66  Carcinoma in situ of cervix uteri

Exclusions:

  • melanoma in situ of cervix (2E63)
  • severe dysplasia of cervix NOS (GA13.1)

2E66.0 Cervical intraepithelial neoplasia grade II

Definition of Cervical intraepithelial neoplasia grade II: A condition of the cervix, caused by chronic infection of the cervix with human papillomavirus. This condition is characterised by premalignant transformation and moderate dysplasia of the cervix confined to the basal two thirds of the squamous epithelial cells on the surface of the tissue. Confirmation is by the Papanicolaou smear test followed by a biopsy of any abnormal cell growth.

Inclusions:

  • moderate cervical dysplasia

2E66.1 Cervical intraepithelial neoplasia grade III

Definition of Cervical intraepithelial neoplasia grade III: A condition of the cervix, caused by chronic infection with human papillomavirus. This condition is characterised by premalignant transformation and severe dysplasia of the cervix that spans more than two thirds of the squamous epithelial cells on the surface of the tissue. Confirmation is by the Papanicolaou smear test followed by a biopsy of any abnormal cell growth.

Inclusions:

  • severe cervical dysplasia and carcinoma in-situ

2E66.Y Other specified carcinoma in situ of cervix uteri

2E66.Z Carcinoma in situ of cervix uteri unspecified

Carcinoma in situ of other or unspecified genital organs

ICD 11 Code For Carcinoma in situ of other or unspecified genital organs

  2E67  Carcinoma in situ of other or unspecified genital organs

Exclusions:

  • Melanoma in situ neoplasms (2E63)

2E67.0 Carcinoma in situ of endometrium

2E67.1 Carcinoma in situ of vulva

Exclusions:

  • severe dysplasia of vulva NOS (GA13.1)

2E67.10 Vulvar intraepithelial neoplasia

Definition of Vulvar intraepithelial neoplasia: A precancerous neoplastic process characterised by dysplasia and maturation abnormalities of the vulvar squamous epithelium. There is no evidence of invasion. It is associated with human papillomavirus infection and is classified as low or high grade.

2E67.11 Vulvar Paget disease

Definition of Vulvar Paget disease: An uncommon intraepithelial malignant neoplasm of eccrine or apocrine origin, arising from the vulva. It usually affects post-menopausal women. In approximately 10-20% of the cases there is an associated anorectal, or urothelial carcinoma or a skin appendage adenocarcinoma identified. It presents as a red, eczematous lesion. Microscopically, it is characterised by the presence of the typical Paget cells which are large, round cells with abundant cytoplasm and prominent nuclei.

2E67.2 Carcinoma in situ of vagina

2E67.20 Vaginal intraepithelial neoplasia grade II

Definition of Vaginal intraepithelial neoplasia grade II: A condition of the vagina, characterised by lesions of the squamous vaginal intraepithelial cells, leading to dysplasia, varying degrees of atypia, and abnormal cell growth within two thirds of the vaginal skin. This condition may be associated with human papillomavirus infection. Confirmation is by the Papanicolaou smear test followed by a biopsy of any abnormal cell growth.

Inclusions:

  • moderate vaginal dysplasia

2E67.21 Vaginal intraepithelial neoplasia grade III

Definition of Vaginal intraepithelial neoplasia grade III: A condition of the vagina, characterised by lesions of the squamous vaginal intraepithelial cells and carcinoma in situ, leading to dysplasia, varying degrees of atypia, and abnormal cell growth within the full thickness of the vaginal skin. This condition may be associated with human papillomavirus infection. Confirmation is by the Papanicolaou smear test followed by a biopsy of any abnormal cell growth.

Inclusions:

  • severe vaginal dysplasia and carcinoma in-situ

2E67.2Y Other specified carcinoma in situ of vagina

2E67.2Z Carcinoma in situ of vagina unspecified

2E67.3 Carcinoma in situ of other or unspecified female genital organs

2E67.4 Carcinoma in situ of penis

Definition of Carcinoma in situ of penis: This comprises both squamous carcinoma in situ and extramammary Paget disease of the penis. The former is an uncommon precancerous disease of penile skin. Lesions usually appear on the glans or inner aspect of the foreskin and are almost always found in uncircumcised men. If left untreated, 10-30% of cases develop into invasive squamous cell carcinoma of the penis. When it affects the skin of the shaft or prepuce it is commonly called Bowen disease. If it affects the glans or inner surface of the prepuce it may also be referred to as penile intraepithelial neoplasia (or in the past as erythroplasia of Queyrat). Extramammary Paget disease of penis is a rare form of carcinoma in situ involving penile skin or glans penis.

Coded Elsewhere:

  • Extramammary Paget disease of penis (2E64.1)

2E67.40 Squamous cell carcinoma in situ of skin of penis

Definition of Squamous cell carcinoma in situ of skin of penis: Squamous cell carcinoma affecting the skin of the prepuce or of the shaft of the penis and commonly called Bowen disease. HPV infection and chronic exposure to psoralen photochemotherapy are predisposing factors.

Inclusions:

  • Bowen disease of skin of penis

2E67.41 Squamous cell carcinoma in situ of mucocutaneous epithelium of penis

Inclusions:

  • Penile intraepithelial neoplasia of inner preputial epithelium
  • Penile intraepithelial neoplasia of glans penis

2E67.5 Carcinoma in situ of prostate

Definition of Carcinoma in situ of prostate: High grade prostatic intraepithelial neoplasia characterised by the presence of severe architectural and cytologic abnormalities.

Inclusions:

  • high grade prostatic intraepithelial neoplasia

Exclusions:

  • low grade dysplasia of prostate (GA91.6)

2E67.6 Carcinoma in situ of other or unspecified male genital organs

Carcinoma in situ of bladder

Definition of Carcinoma in situ of bladder: Stage 0is includes: Tis, N0, M0. Tis: Carcinoma in situ: flat tumour. N0: No regional lymph node metastasis. M0: No distant metastasis.

ICD 11 Code For Carcinoma in situ of bladder

  2E68  Carcinoma in situ of bladder

Carcinoma in situ of other or unspecified urinary organs

ICD 11 Code For Carcinoma in situ of other or unspecified urinary organs

  2E69  Carcinoma in situ of other or unspecified urinary organs

Carcinoma in situ of the eye or ocular adnexa

ICD 11 Code For Carcinoma in situ of the eye or ocular adnexa

  2E6A  Carcinoma in situ of the eye or ocular adnexa

2E6A.0 Carcinoma in situ of the conjunctiva

Exclusions:

  • Melanoma in situ of conjunctiva (2E63.1)

2E6A.1 Carcinoma in situ of the cornea

2E6A.Y Carcinoma in situ of other and unspecified part of the eye and adnexa

Carcinoma in situ of thyroid and other endocrine glands

ICD 11 Code For Carcinoma in situ of thyroid and other endocrine glands

  2E6B  Carcinoma in situ of thyroid and other endocrine glands

Exclusions:

  • Carcinoma in situ of ovary (2E67.3)
  • Carcinoma in situ of testis (2E67.6)

Carcinoma in situ of other specified site

ICD 11 Code For Carcinoma in situ of other specified site

  2E6Y  Carcinoma in situ of other specified site

Carcinoma in situ of unspecified site

ICD 11 Code For Carcinoma in situ of unspecified site

  2E6Z  Carcinoma in situ of unspecified site

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