Definition of Myelodysplastic Syndromes: hematopoietic disorders characterised by dysplasia and ineffective hematopoiesis in one or more of the hematopoietic cell lines. The dysplasia may be accompanied by an increase in myeloblasts, but the number is less than 20% in marrow and blood, which, according to the WHO guidelines, is the requisite threshold for the diagnosis of acute myeloid leukaemia.
2A30 Refractory anaemia
Definition of Refractory neutropaenia: A myelodysplastic syndrome characterised by the presence of at least 10% dysplastic neutrophils in the bone marrow or the peripheral blood.
2A31 Refractory neutropaenia
Definition of Refractory thrombocytopenia: A myelodysplastic syndrome characterised by the presence of at least 10% dysplastic megakaryocytes, found within at least 30 megakaryocytes examined in the bone marrow.
2A32 Refractory thrombocytopenia
Definition of Refractory anaemia with ring sideroblasts: A myelodysplastic syndrome characterised by an anaemia in which 15% or more of the erythroid precursors are ringed sideroblasts. The ring sideroblast is an erythroid precursor in which one third or more of the nucleus is encircled by granules which are positive for iron stain.
2A33 Refractory anaemia with ring sideroblasts
Definition of Refractory cytopenia with multi-lineage dysplasia: A myelodysplastic syndrome characterised by bi-cytopenia or pancytopenia and dysplastic changes in 10% or more of the cells in two or more of the myeloid cell lines.
2A34 Refractory cytopenia with multi-lineage dysplasia
Definition of Refractory anaemia with excess of blasts: A myelodysplastic syndrome characterised by bi-cytopenia or pancytopenia and dysplastic changes in one or multiple lineages, with 5-19% myeloblasts in the bone marrow, 2-19% blasts in the blood, or <20% blasts with the presence of Auer rods.
2A35 Refractory anaemia with excess of blasts
Definition of Myelodysplastic syndrome with isolated del(5q): A myelodysplastic syndrome characterised by anaemia with or without other cytopenias and/or thrombocytosis and in which the sole cytogenetic abnormality is del(5q). Myeloblasts are <5% in the bone marrow and <1% in the blood.
2A36 Myelodysplastic syndrome with isolated del(5q)
Definition of Myelodysplastic syndrome unclassifiable: A subtype of myelodysplastic syndrome which at disease presentation lacks findings appropriate for classification into any other MDS category, or has an MDS-associated cytogenetic abnormality and cytopenia, but lack sufficient dysplastic changes in any lineage and have <15% ring sideroblasts.
2A37 Myelodysplastic syndrome unclassifiable
Definition of Refractory cytopenia of childhood: The most common subtype of the myelodysplastic syndromes affecting children. It is characterised by persistent cytopenia with less than 5% blasts in the bone marrow and less than 2% blasts in the peripheral blood.
2A38 Refractory cytopenia of childhood
2A3Y Other specified myelodysplastic syndromes
2A3Z Myelodysplastic syndromes unspecified
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