1F50, 1F51, 1F51.0, 1F52, 1F53, 1F54, 1F55, 1F56, 1F57, 1F58, 1F5Z

Nonintestinal Protozoal Diseases – ICD 11 Codes

Definition of Nonintestinal Protozoal Diseases: Infections with unicellular organisms of the subkingdom Protozoa.

Exclusions:

  • Protozoal intestinal infections (BlockL2‑1A3)

Coded Elsewhere:

  • Amoebiasis (1A36)
  • Malaria without parasitological confirmation (1F45)
  • Protozoal diseases complicating pregnancy, childbirth or the puerperium (JB63.6)

Acanthamoebiasis

ICD 11 Code For Acanthamoebiasis

  1F50  Acanthamoebiasis

African trypanosomiasis

Definition of African trypanosomiasis: A disease caused by an infection with the protozoan parasite Trypanosoma brucei. This disease presents with symptoms depending on the form of the protozoan parasite (Trypanosoma brucei rhodesiense or Trypanosoma brucei gambiense). Transmission is through the bite of an infected tsetse fly. Confirmation is by identification of Trypanosoma brucei in a blood or tissue sample.

ICD 11 Code For African trypanosomiasis

  1F51  African trypanosomiasis

Gambiense trypanosomiasis

Definition of Gambiense trypanosomiasis: A disease caused by an infection with the protozoan parasite Trypanosoma brucei gambiense. This disease is characterised by fever, headache, muscle and joint aches, or malaise. This disease may also present with lymphadenopathy, weight loss, or neurological deficits. Transmission is through the bite of an infected tsetse fly. Confirmation is by identification of Trypanosoma brucei gambiense in a biopsy of the lymph node.

ICD 11 Code For Gambiense trypanosomiasis

1F51.0 Gambiense trypanosomiasis

Inclusions:

  • West African sleeping sickness
  • Infection due to Trypanosoma brucei gambiense

1F51.00 Meningitis in Gambiense trypanosomiasis

1F51.0Y Other specified gambiense trypanosomiasis

1F51.0Z Gambiense trypanosomiasis unspecified

1F51.1 Rhodesiense trypanosomiasis

Definition of Rhodesiense trypanosomiasis: A disease caused by an infection with the protozoan parasite Trypanosoma brucei rhodesiense. This disease is characterised by a chancre at the site of the bite. This disease may also present with fever, headache, muscle and joint aches, or lymphadenopathy. Transmission is through the bite of an infected tsetse fly. Confirmation is by identification of Trypanosoma brucei rhodesiense in a blood sample, lymph node fluid, or biopsy of the chancre.

Inclusions:

  • East African sleeping sickness
  • Infection due to Trypanosoma brucei rhodesiense

1F51.10 Meningitis in Rhodesiense trypanosomiasis

1F51.1Y Other specified rhodesiense trypanosomiasis

1F51.1Z Rhodesiense trypanosomiasis unspecified

1F51.Y Other specified african trypanosomiasis

1F51.Z African trypanosomiasis unspecified

Babesiosis

Definition of Babesiosis: A disease caused by the protozoan parasite Babesia. This disease is characterised by reproduction and lysis of erythrocytes leading to symptoms that depend on the level of parasitaemia and immune status of the infected individual. This disease may present with fever, chills, malaise, myalgia, haemolytic anaemia, shock, or may be asymptomatic. Transmission is through the bite of an infected tick (Ixodes), or vertical transmission. Confirmation is by identification of Babesia in a blood smear, or detection of antibodies against Babesia.

ICD 11 Code For Babesiosis

  1F52  Babesiosis

Inclusions:

  • Piroplasmosis

Chagas disease

Definition of Chagas disease: A disease caused by an infection with the protozoan parasite Trypanosoma cruzi. This disease is characterised by fever, headache, lymphadenopathy, pallor, muscle pain, dyspnoea, swelling, or abdominal or chest pain. This disease may also be asymptomatic. Transmission is by direct contact with faeces from an infected triatomine bug, vertical transmission, iatrogenic transmission, or ingestion of contaminated food or water. Confirmation is by identification of Trypanosoma cruzi in a blood sample.

ICD 11 Code For Chagas disease

  1F53  Chagas disease

Inclusions:

  • American trypanosomiasis
  • infection due to Trypanosoma cruzi

1F53.1 Acute Chagas disease without heart involvement

Definition of Acute Chagas disease without heart involvement: A disease caused by an acute infection with the protozoan parasite Trypanosoma cruzi. This disease is characterised by fever, headache, lymphadenopathy, pallor, muscle pain, dyspnoea, swelling, or abdominal or chest pain. This disease presents with no cardiac involvement. Transmission is by direct contact with faeces from an infected triatomine bug, vertical transmission, iatrogenic transmission, or ingestion of contaminated food or water. Confirmation is by identification of Trypanosoma cruzi in a blood sample.

1F53.2 Chronic Chagas disease with heart involvement

Definition of Chronic Chagas disease with heart involvement: A disease caused by a chronic infection with the protozoan parasite Trypanosoma cruzi. This disease commonly presents with severe malaise or cardiac involvement (such as cardiomyopathy, cardiac failure, thromboembolism, bradyarrhythmias, tachyarrhythmias, apical aneurysms, or cardiac arrest). Transmission is by direct contact with faeces from an infected triatomine bug, vertical transmission, iatrogenic transmission, or ingestion of contaminated food or water. Confirmation is by identification of Trypanosoma cruzi in a blood sample.

1F53.3 Chagas disease with digestive system involvement

Definition of Chagas disease with digestive system involvement: A disease caused by an infection with the protozoan parasite Trypanosoma cruzi. This disease is characterised by severe malaise or digestive system involvement (such as megaoesophagus or megacolon). Transmission is by direct contact with faeces from an infected triatomine bug, vertical transmission, iatrogenic transmission, or ingestion of contaminated food or water. Confirmation is by identification of Trypanosoma cruzi in a blood sample.

1F53.4 Meningitis in Chagas disease

1F53.Y Other specified Chagas disease

1F53.Z Chagas disease unspecified

Leishmaniasis

Definition of Leishmaniasis: Leishmaniasis is due to infection by vector-borne protozoa from the genus Leishmania. These protozoa exist as obligate intracellular parasites in human and mammalian hosts and are transmitted form host to host by certain species of sandfly. Depending on the Leishmania species involved, the resultant disease picture may range from a localised cutaneous ulcer through extensive mucocutaneous destruction to severe systemic disease.

ICD 11 Code For Leishmaniasis

  1F54  Leishmaniasis

1F54.0 Visceral leishmaniasis

Definition of Visceral leishmaniasis: A disease caused by an infection with the protozoan parasite Leishmania. This disease is characterised by biphasic fever, hepatosplenomegaly, pancytopenia, wasting, darkening of the skin, or may be asymptomatic. Transmission is through the bite of an infected female phlebotomine sandfly. Confirmation is by identification of Leishmania from a tissue or blood sample, or detection of antibodies against Leishmania.

Inclusions:

  • Kala-azar

1F54.1 Cutaneous leishmaniasis

Definition of Cutaneous leishmaniasis: Cutaneous leishmaniasis results from bites by sandflies infected by protozoan parasites of the genus Leishmania. Phlebotomus is the principal vector in the Old World (Mediterranean, North Africa, Ethiopia and Asia), where L. major, L. tropica, L. aethiopica and L. donovani infantum predominate. Other sandflies are responsible for transmitting the New World species, L. mexicana and L. brasiliensis. The commonest presentation is with one or more crusted nodules or ulcers on exposed sites which gradually heal with scarring. Mexican and Ethiopian forms have a tendency to cause diffuse infiltration of the skin; South American forms frequently progress to mucocutaneous leishmaniasis.

Coded Elsewhere:

  • Post-kala-azar dermal leishmaniasis (1F54.0)

1F54.2 Mucocutaneous leishmaniasis

Definition of Mucocutaneous leishmaniasis: Mucocutaneous leishmaniasis is a secondary infection of nasal and oral mucosae, predominantly by Leishmania braziliensis. It usually first manifests within two years of initial cutaneous infection but often after the latter has healed. It results from lymphatic or haematogenous spread of infection and can cause severe local tissue destruction.

Inclusions:

  • Leishmania braziliensis infection

1F54.Z Leishmaniasis unspecified

Naegleriasis

Definition of Naegleriasis: Any condition caused by an infection with the protozoan parasite Naegleria.

ICD 11 Code For Naegleriasis

  1F55  Naegleriasis

Coded Elsewhere:

  • Primary amoebic meningoencephalitis (1D00.2)

Rhinosporidiosis

Definition of Rhinosporidiosis: Rhinosporidiosis is a chronic, usually painless localised infection of the mucous membranes. Formerly believed to be a fungus, the causative agent, Rhinosporidium seeberi, has also never been cultured. With 18S r DNA sequencing, this organism has been shown to be a protistan parasite. Rhinosporidiosis occurs worldwide, and the greatest numbers of cases are found in southern India and Sri Lanka.

ICD 11 Code For Rhinosporidiosis

  1F56  Rhinosporidiosis

Toxoplasmosis

Definition of Toxoplasmosis: A disease caused by an infection with the protozoan parasite Toxoplasma gondii. This disease is characterised by fever, lymphadenitis, sore throat, or rash. Transmission is by direct ingestion of contaminated food, indirectly by food or water contaminated with infected cat faeces, or vertical transmission. Confirmation is by detection of antibodies against Toxoplasma gondii, or identification of Toxoplasma gondii in tissue, cerebrospinal fluid, blood, or other body fluids.

ICD 11 Code For Toxoplasmosis

  1F57  Toxoplasmosis

Coded Elsewhere:

  • Congenital toxoplasmosis (KA64.0)

1F57.0 Hepatitis due to Toxoplasma gondii

Definition of Hepatitis due to Toxoplasma gondii: A disease of the liver, caused by an infection with the protozoan parasite Toxoplasma gondii. This disease is characterised by jaundice. Transmission is by haematogenous spread to the liver after direct ingestion of contaminated food, or indirect transmission by consumption of food or water contaminated with infected cat faeces. Confirmation is by detection of antibodies against Toxoplasma gondii in a blood sample or identification of Toxoplasma gondii in hepatic tissue.

1F57.1 Meningoencephalitis due to Toxoplasma gondii

Definition of Meningoencephalitis due to Toxoplasma gondii: A disease of the meninges and brain, caused by an infection with the protozoan parasite Toxoplasma gondii. This disease is characterised by seizures, neck pain, neurological deficits, or alterations in behaviour, cognition, or consciousness. Transmission is by haematogenous spread to the meninges and brain after direct ingestion of contaminated food, or indirect transmission by consumption of food or water contaminated with infected cat faeces. Confirmation is by detection of antibodies against Toxoplasma gondii in cerebrospinal fluid or identification of Toxoplasma gondii in cerebrospinal fluid, and advanced imaging of the nervous system.

Inclusions:

  • Toxoplasma meningoencephalitis

1F57.2 Pulmonary toxoplasmosis due to Toxoplasma gondii

Definition of Pulmonary toxoplasmosis due to Toxoplasma gondii: In immunodeficient patients, toxoplasmosis most often occurs in persons with defects in T cell–mediated immunity such as those receiving corticosteroids, anti–tumour necrosis factor (TNF) therapies, or cytotoxic drugs and those with hematologic malignancies, organ transplants, or acquired immunodeficiency syndrome (AIDS).

Pulmonary toxoplasmosis in the immunodeficient patient may appear in the form of interstitial pneumonitis, necrotizing pneumonitis, consolidation, pleural effusion, or empyema, or all of these.[1]

AIDS patients with Toxoplasma pneumonia present with cough, dyspnoea, and fever. As toxoplasmosis is generally seen only in advanced HIV infection with CD4 counts below 100, the majority of AIDS patients who develop toxoplasma pneumonia already have had previous HIV-associated opportunistic infections. In solid organ transplant patients, this is most commonly due to transplantation of a toxoplasma-seropositive lung or heart into a seronegative recipient, resulting in primary pulmonary disease. In bone marrow transplant patients, pulmonary toxoplasmosis occurs in 0.28% to 0.45% of patients. Unlike solid organ transplant patients, most of these patients have reactivation, not primary disease.[2]

Source:

[1] Montoya JG, et al. Toxoplasma gondii. In: edited by Mandell GL, Bennett JE, Dolin R, Mandell, Douglas, and Bennett’s principles and practice of infectious diseases7th ed. Philadelphia: Churchill Livingstone, 2010.3495-3526

[2] McCarthy J, et al. PARASITIC LUNG INFECTIONS. In: Robert J. Mason BJ et al. editors. Murray & Nadel’s textbook of respiratory medicine. 5th ed. Philadelphia: Saunders Elsevier: 2010. p.661-698

Inclusions:

  • Pulmonary toxoplasmosis

1F57.3 Eye disease due to Toxoplasma gondii

Definition of Eye disease due to Toxoplasma gondii: Chorioretinitis or ocular toxoplasmosis is a relatively common manifestation of T. gondii infection. Ocular toxoplasmosis occurs when cysts deposited in or near the retina become active, producing tachyzoites. Focal necrotizing retinitis is the characteristic lesion, but retinal scars from prior reactivation are typically present.

Inclusions:

  • Toxoplasma oculopathy

1F57.Y Other specified toxoplasmosis

1F57.Z Toxoplasmosis unspecified

Microsporidiosis

ICD 11 Code For Microsporidiosis

  1F58  Microsporidiosis

Unspecified protozoal disease

ICD 11 Code For Unspecified protozoal disease

  1F5Z  Unspecified protozoal disease

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