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CPT®
0506T

CPT® Code 0506T

Official Description

Macular pigment optical density measurement by heterochromatic flicker photometry, unilateral or bilateral, with interpretation and report

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

Macular pigment optical density (MPOD) measurement by heterochromatic flicker photometry is a non-invasive diagnostic procedure that evaluates the density of a specific yellow pigment located in the fovea of the macula, which is the central part of the retina. This pigment, composed of carotenoids such as lutein, meso-zeaxanthin, and zeaxanthin, plays a crucial role in protecting the eye from harmful blue light, which can cause damage to photoreceptors. The measurement of MPOD is significant because low levels of macular pigment are associated with an increased risk of age-related macular degeneration (AMD), a leading cause of vision loss in older adults. The procedure assesses the thickness of this pigment, which can vary among individuals due to factors such as age, genetic predisposition, dietary habits, and lifestyle choices. Symptoms that may indicate thinning of the macular pigment include decreased visual acuity, reduced contrast sensitivity, prolonged glare recovery, and photophobia. During the test, each eye is evaluated separately while the patient focuses on a target. A specialized optical camera introduces a monochromatic blue light with varying wavelengths and intensities, and the responses are recorded and analyzed using computer software. The resulting MPOD measurements are expressed on a scale from 0 to 1, with lower scores indicating a higher risk for developing AMD. This procedure is essential for comprehensive patient risk assessment and the formulation of appropriate treatment plans.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The macular pigment optical density measurement by heterochromatic flicker photometry is indicated for the following conditions:

  • Age-Related Macular Degeneration (AMD) - This procedure is performed to assess the risk of developing AMD, which is characterized by the deterioration of the macula and can lead to significant vision loss.
  • Visual Acuity Loss - Patients experiencing a decline in visual acuity may undergo this test to evaluate the health of the macula and the density of macular pigment.
  • Contrast Sensitivity Issues - Individuals with difficulties in distinguishing between different levels of contrast may benefit from this measurement to determine if low macular pigment density is a contributing factor.
  • Glare Recovery Problems - Patients who have prolonged glare recovery may be assessed for macular pigment density to understand its impact on their visual function.
  • Photophobia - Those experiencing sensitivity to light may undergo this test to evaluate the protective role of macular pigment against harmful blue light.

2. Procedure

The procedure for macular pigment optical density measurement involves several key steps:

  • Patient Positioning The patient is positioned in front of an optical camera, ensuring that they are comfortable and able to focus on a designated target during the test.
  • Target Focus The patient is instructed to focus on a specific target within the optical device, which helps to stabilize the eye and ensure accurate measurements.
  • Light Introduction A monochromatic blue light is introduced to the eye. This light has alternating wavelengths and varying intensities, which are crucial for eliciting the necessary responses from the macular pigment.
  • Response Observation The responses of the eye to the introduced light are carefully observed and recorded. This data is essential for determining the density of the macular pigment.
  • Data Analysis The recorded responses are downloaded into a specialized computer software program that analyzes the data and calculates the macular pigment optical density measurements.

3. Post-Procedure

After the procedure, patients may receive a report detailing their macular pigment optical density measurements. This report is crucial for understanding the patient's risk for age-related macular degeneration and for developing a comprehensive treatment plan. Patients may be advised on dietary and lifestyle modifications to improve or maintain their macular pigment density. Follow-up appointments may be scheduled to monitor changes in macular pigment density over time and to assess any progression of visual symptoms.
Short Descr MAC PGMT OPT DNS MEAS HFP
Medium Descr MAC PGMT OPTICAL DNS MEAS HFP UNI/BI W/I&R
Long Descr Macular pigment optical density measurement by heterochromatic flicker photometry, unilateral or bilateral, with interpretation and report
Status Code Carriers Price the Code
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 1 - Diagnostic Tests for Radiology Services
Multiple Procedures (51) 7 - Special payment adjustment rules on the technical component (TC) of multiple diagnostic ophthalmology services apply...
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 0 - Payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator STV-Packaged Codes
Berenson-Eggers TOS (BETOS) none
MUE 1
GA Waiver of liability statement issued as required by payer policy, individual case
RT Right side (used to identify procedures performed on the right side of the body)
Date
Action
Notes
2019-01-01 Added First appearance in codebook.
2018-07-01 Added Code added.
2018-01-01 Added Code added.
Code
Description
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