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Official Description

Autologous cellular implant derived from adipose tissue for the treatment of osteoarthritis of the knees; tissue harvesting and cellular implant creation

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The procedure described by CPT® Code 0565T involves the use of an autologous cellular implant derived from adipose tissue specifically for the treatment of osteoarthritis of the knees. Osteoarthritis is a prevalent chronic condition characterized by the degeneration of joint cartilage, leading to symptoms such as swelling, stiffness, and pain in the knee joints. As the condition advances, it can result in the formation of bone spurs within the knee, exacerbated by the presence of cytokines and enzymes that further contribute to cartilage degradation. This innovative procedure represents a form of regenerative therapy aimed at alleviating the symptoms of knee osteoarthritis through the utilization of the patient's own adipose tissue. During the procedure, adipose tissue is harvested from the patient, typically from areas with excess fat such as the abdomen, flank, or thigh, using techniques like subcutaneous liposuction. The harvested tissue is then processed to extract mesenchymal stem cells, which are known for their regenerative properties. This processing may involve methods such as centrifugation, sedimentation, or washing and filtration to enhance the concentration of stem cells while eliminating contaminants. Following the preparation of the cellular implant, the procedure includes the implantation of the processed adipose tissue directly into the affected area of the knee, often guided by ultrasound to ensure precision. This approach leverages the higher concentration of stem cells found in adipose tissue compared to other sources, such as bone marrow, making it a promising option for patients suffering from knee osteoarthritis.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The procedure associated with CPT® Code 0565T is indicated for the treatment of osteoarthritis of the knees. This condition is characterized by the breakdown of joint cartilage, leading to various symptoms and complications. The following are specific indications for this procedure:

  • Osteoarthritis of the knees - A chronic condition where the cartilage in the knee joint deteriorates, resulting in pain, swelling, and stiffness.

2. Procedure

The procedure for CPT® Code 0565T involves several critical steps to ensure the effective treatment of knee osteoarthritis through the use of autologous adipose-derived cellular implants. The following steps outline the procedure:

  • Step 1: Tissue Harvesting - The first step involves harvesting adipose tissue from the patient. This is typically performed using subcutaneous liposuction techniques, targeting areas with excess fat such as the abdomen, flank, or thigh. The procedure may utilize a syringe or cannula to aspirate the fat tissue, ensuring a sufficient quantity is collected for processing.
  • Step 2: Processing of Adipose Tissue - Once the adipose tissue is harvested, it undergoes processing to derive mesenchymal stem cells. This processing may include methods such as centrifugation, sedimentation, or washing and filtration. These techniques are employed to increase the concentration of stem cells while removing contaminants, including cellular debris, oils, and blood cells, thereby preparing a viable cellular implant.
  • Step 3: Implantation of the Cellular Graft - After processing, the next step is the implantation of the adipose-derived graft into the knee joint. This is typically performed through one or multiple small incisions made over the knee. The implantation is conducted using a needle or small-gauge cannula, often under ultrasound guidance to ensure accurate placement. Prior to injecting the adipose-derived graft, synovial fluid is withdrawn from the joint to create space for the implant.

3. Post-Procedure

Post-procedure care following the implantation of the autologous cellular implant is essential for optimal recovery and outcomes. Patients may experience some swelling and discomfort in the knee area, which is typically managed with standard post-operative care protocols. It is important for patients to follow their physician's instructions regarding activity restrictions and rehabilitation exercises to promote healing. Regular follow-up appointments may be scheduled to monitor the patient's progress and assess the effectiveness of the treatment in alleviating symptoms associated with knee osteoarthritis.

Short Descr AUTOL CELL IMPLT ADPS HRVG
Medium Descr AUTOL CELL IMPLT ADPS TISS HRVG CELL IMPLT CRTJ
Long Descr Autologous cellular implant derived from adipose tissue for the treatment of osteoarthritis of the knees; tissue harvesting and cellular implant creation
Status Code Carriers Price the Code
Global Days YYY - Carrier Determines Whether Global Concept Applies
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 0 - No payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 0 - Payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Non-Covered Service, not paid under OPPS
Berenson-Eggers TOS (BETOS) none
MUE 1
AS Physician assistant, nurse practitioner, or clinical nurse specialist services for assistant at surgery
GA Waiver of liability statement issued as required by payer policy, individual case
LT Left side (used to identify procedures performed on the left side of the body)
RT Right side (used to identify procedures performed on the right side of the body)
Date
Action
Notes
2020-01-01 Added Code added.
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