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Official Description

Esophagogastroduodenoscopy, flexible, transnasal; with biopsy, single or multiple

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The procedure described by CPT® Code 0653T refers to a flexible transnasal esophagogastroduodenoscopy (EGD) that includes the performance of biopsies, which may involve taking single or multiple tissue samples. This diagnostic procedure utilizes a flexible endoscope, a specialized instrument designed to visualize the upper gastrointestinal tract, including the esophagus, stomach, and duodenum. The endoscope is introduced through the nasal passage, allowing for a less invasive approach compared to traditional oral endoscopy. During the procedure, the physician examines critical anatomical structures such as the velopharyngeal closure, base of the tongue, and hypopharynx, while also assessing vocal cord motion and pharyngeal musculature. As the endoscope is advanced, it traverses the esophagus to the gastroesophageal junction, where any abnormalities can be noted. The examination continues into the stomach, where the cardia, fundus, greater and lesser curvature, and antrum are inspected. The procedure allows for the collection of tissue samples from suspicious areas, which can be crucial for diagnosing various gastrointestinal conditions. Additionally, the endoscope can be advanced into the duodenum and jejunum to inspect mucosal surfaces for abnormalities. The procedure may also involve cytology sampling through brushing or washing techniques, enhancing the diagnostic capabilities of the EGD. Overall, this procedure is essential for evaluating and diagnosing conditions affecting the upper gastrointestinal tract, providing valuable insights for further management and treatment.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The procedure described by CPT® Code 0653T is indicated for various clinical scenarios where visualization and biopsy of the upper gastrointestinal tract are necessary. The following conditions may warrant the performance of this procedure:

  • Suspicious Lesions: The presence of abnormal growths or lesions in the esophagus, stomach, or duodenum that require histological evaluation.
  • Unexplained Gastrointestinal Symptoms: Patients presenting with symptoms such as dysphagia (difficulty swallowing), odynophagia (painful swallowing), or gastrointestinal bleeding may necessitate this procedure for diagnosis.
  • Monitoring of Known Conditions: Patients with a history of gastrointestinal disorders, such as Barrett's esophagus or peptic ulcers, may require surveillance through biopsy to assess for changes or progression of disease.
  • Evaluation of Inflammatory Conditions: Conditions such as gastritis or esophagitis that may require tissue sampling for definitive diagnosis and management.

2. Procedure

The procedure involves several key steps that ensure thorough examination and sampling of the upper gastrointestinal tract:

  • Step 1: The flexible endoscope is introduced through the nasal passage, allowing for a transnasal approach. This method is less invasive and can enhance patient comfort compared to traditional oral endoscopy.
  • Step 2: Once the endoscope is in place, the physician examines the velopharyngeal closure, base of the tongue, and hypopharynx. Vocal cord motion is assessed, and the pharyngeal musculature is evaluated to ensure proper function.
  • Step 3: The endoscope is advanced to the cricopharyngeus, where the patient may be instructed to burp or swallow to facilitate the passage of the scope into the esophagus.
  • Step 4: The endoscope is then advanced through the entire length of the esophagus to the gastroesophageal junction, where the esophagus is inspected for any abnormalities.
  • Step 5: The endoscope continues into the stomach, which is insufflated with air to improve visibility. The cardia, fundus, greater and lesser curvature, and antrum are thoroughly examined for any signs of pathology.
  • Step 6: The endoscope is advanced through the pylorus into the duodenum and/or jejunum, where the mucosal surfaces are inspected for abnormalities.
  • Step 7: During the procedure, single or multiple tissue samples may be collected through the endoscope for biopsy. Cytology samples can also be obtained through brushing or washing techniques, enhancing diagnostic accuracy.
  • Step 8: If necessary, a transendoscopic tube or catheter may be placed for nutritional support in patients with impaired swallowing. This involves inserting a nasoenteric tube into the stomach, reintroducing the endoscope, and advancing the tube through the pylorus into the duodenum.
  • Step 9: The endoscope is then withdrawn, and the mucosal surfaces are re-inspected for any ulcerations, varices, bleeding sites, lesions, strictures, or other abnormalities before concluding the procedure.

3. Post-Procedure

After the completion of the esophagogastroduodenoscopy, patients may be monitored for any immediate complications, such as bleeding or perforation. It is common for patients to experience some throat discomfort or mild sedation effects if anesthesia was used. Recovery time may vary, but patients are typically advised to rest and avoid strenuous activities for the remainder of the day. Follow-up appointments may be scheduled to discuss biopsy results and any further management based on findings during the procedure. Additionally, patients should be informed about signs of potential complications, such as severe abdominal pain, fever, or difficulty swallowing, which would require immediate medical attention.

Short Descr EGD FLX TRANSNASAL BX 1/MLT
Medium Descr EGD FLEXIBLE TRANSNASAL W/BIOPSY SINGLE/MULTIPLE
Long Descr Esophagogastroduodenoscopy, flexible, transnasal; with biopsy, single or multiple
Status Code Carriers Price the Code
Global Days YYY - Carrier Determines Whether Global Concept Applies
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 3 - Special payment adjustment rules for multiple endoscopic procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 1 - Statutory payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Endoscopic Base Code 0652T  Esophagogastroduodenoscopy, flexible, transnasal; diagnostic, including collection of specimen(s) by brushing or washing, when performed (separate procedure)
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Hospital Part B services paid through a comprehensive APC
ASC Payment Indicator Non office-based surgical procedure added in CY 2008 or later; payment based on OPPS relative payment weight.
Berenson-Eggers TOS (BETOS) none
MUE 1
51 Multiple procedures: when multiple procedures, other than e/m services, physical medicine and rehabilitation services or provision of supplies (eg, vaccines), are performed at the same session by the same individual, the primary procedure or service may be reported as listed. the additional procedure(s) or service(s) may be identified by appending modifier 51 to the additional procedure or service code(s). note: this modifier should not be appended to designated "add-on" codes (see appendix d).
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
Date
Action
Notes
2022-01-01 Added First appearance in codebook.
2021-07-01 Added Code added.
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