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Official Description

Autologous adipose-derived regenerative cell (ADRC) therapy for partial thickness rotator cuff tear; adipose tissue harvesting, isolation and preparation of harvested cells, including incubation with cell dissociation enzymes, filtration, washing, and concentration of ADRCs

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

Autologous adipose-derived regenerative cell (ADRC) therapy is a medical procedure designed to address partial thickness rotator cuff tears by utilizing the patient's own adipose (fat) tissue. This innovative approach aims to enhance the healing process of the tendons surrounding the shoulder joint. Traditional conservative treatments, such as physical therapy or steroid injections, may alleviate symptoms but do not facilitate the actual repair of a torn rotator cuff. Surgical interventions can be effective; however, they carry a significant risk of re-rupture. One contributing factor to the rotator cuff's limited healing capacity is the inadequate supply of stem cells, which are essential for the development of connective tissue, lymphatic tissue, or blood vessels at the tendon-bone interface. The ADRC therapy process involves several critical steps, including the harvesting, cleaning, filtering, and processing of adipose tissue. Initially, adipose tissue is obtained from the patient, typically through a procedure known as liposuction, which is performed under local anesthesia in areas such as the trunk or thigh. Once harvested, the adipose tissue is allowed to rest, enabling it to separate into distinct components. The tissue then undergoes incubation with specific enzymatic reagents that facilitate cell isolation and dissociation. Following this, the cells are meticulously processed through a series of steps that include filtration, washing, and centrifugation to concentrate the autologous adipose-derived regenerative cells. Ultimately, these prepared cells are injected into the supraspinatus tendon, which is a critical component of the rotator cuff, using an appropriate gauge needle under ultrasonic guidance. The injection site is subsequently dressed to promote healing. While the full efficacy of this procedure is still being explored in clinical trials, preliminary findings indicate promising outcomes in the repair of partially torn rotator cuffs, with a low incidence of side effects and re-tears.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The autologous adipose-derived regenerative cell (ADRC) therapy is indicated for the treatment of partial thickness rotator cuff tears. This procedure is particularly relevant for patients who have not responded adequately to conservative treatments such as physical therapy or steroid injections, which primarily address symptoms rather than the underlying structural damage. The therapy is aimed at promoting healing in the tendons surrounding the shoulder joint, which may be compromised due to insufficient stem cell supply at the tendon-bone interface.

  • Partial Thickness Rotator Cuff Tear This procedure is specifically designed for patients suffering from partial thickness tears of the rotator cuff, where traditional conservative treatments have failed to provide sufficient relief or healing.

2. Procedure

The procedure for autologous adipose-derived regenerative cell (ADRC) therapy involves several detailed steps to ensure the effective harvesting and preparation of adipose tissue for therapeutic use.

  • Step 1: Adipose Tissue Harvesting The first step involves the collection of adipose tissue from the patient, typically performed through liposuction. This is done under local anesthesia to minimize discomfort. Common harvesting sites include the trunk or thigh, where sufficient fat deposits are available.
  • Step 2: Separation of Adipose Tissue After harvesting, the lipoaspirate is allowed to rest, which facilitates the separation of the adipose tissue from other components. This resting period is crucial for the subsequent processing steps.
  • Step 3: Cell Isolation and Dissociation The separated adipose tissue undergoes incubation with specific enzymatic reagents that assist in the isolation and dissociation of the cells. This enzymatic treatment is essential for preparing the cells for further processing.
  • Step 4: Processing of Cells Following incubation, the cells are subjected to multiple processing steps, including filtration, washing, and centrifugation. These steps are designed to purify and concentrate the autologous adipose-derived regenerative cells (ADRCs) for injection.
  • Step 5: Injection into the Supraspinatus Tendon Once the ADRCs are prepared, they are injected into the supraspinatus tendon and the surrounding area. This injection is performed using an appropriate gauge needle under ultrasonic guidance to ensure accurate placement of the regenerative cells.
  • Step 6: Dressing the Injection Site After the injection, the site is dressed to promote healing and protect the area from infection or complications.

3. Post-Procedure

Post-procedure care for patients undergoing autologous adipose-derived regenerative cell (ADRC) therapy typically involves monitoring the injection site for any signs of infection or complications. Patients may be advised to limit shoulder movement for a specified period to allow for optimal healing of the supraspinatus tendon. Follow-up appointments may be scheduled to assess the healing process and the effectiveness of the treatment. While the procedure is still under investigation in clinical trials, early results suggest a favorable outcome in terms of repairing partially torn rotator cuffs, with a low risk of side effects and re-tears.

Short Descr ADRC THER PRTL RC TEAR
Medium Descr ADRC THER PRTL THICKNESS RC TEAR
Long Descr Autologous adipose-derived regenerative cell (ADRC) therapy for partial thickness rotator cuff tear; adipose tissue harvesting, isolation and preparation of harvested cells, including incubation with cell dissociation enzymes, filtration, washing, and concentration of ADRCs
Status Code Carriers Price the Code
Global Days YYY - Carrier Determines Whether Global Concept Applies
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 2 - Standard payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 1 - 150% payment adjustment for bilateral procedures applies.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 0 - Payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Procedure or Service, Multiple Reduction Applies
ASC Payment Indicator Non office-based surgical procedure added in CY 2008 or later; payment based on OPPS relative payment weight.
Berenson-Eggers TOS (BETOS) none
MUE 1
Date
Action
Notes
2023-01-01 Added First appearance in codebook.
2023-01-01 Changed Code description changed.
2022-07-01 Added Code added.
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