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Official Description

Tissue cultured skin autograft, face, scalp, eyelids, mouth, neck, ears, orbits, genitalia, hands, feet, and/or multiple digits; each additional 100 sq cm, or each additional 1% of body area of infants and children, or part thereof (List separately in addition to code for primary procedure)

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

A tissue cultured skin autograft is a specialized surgical procedure utilized to cover defects in various anatomical areas, including the face, scalp, eyelids, mouth, neck, ears, orbits, genitalia, hands, feet, and multiple digits. This procedure involves the harvesting of epidermal tissue from the patient, which is then processed in a laboratory setting. In the lab, the epidermal cells, known as keratinocytes, are separated from the underlying dermal cells and cultured in a controlled environment, allowing them to proliferate and form sheets of skin. These cultured grafts are essential for treating significant skin loss or damage, providing a viable option for wound coverage. Once the grafts are prepared, they are transported back to the surgical facility in a suitable medium to maintain their viability. During the grafting procedure, the physician carefully removes the graft from its transport medium and positions it over the prepared wound bed. The graft is then secured in place using interrupted sutures, although alternative fixation methods such as staples or fibrin sealant may also be employed. This procedure is particularly relevant for larger areas of skin loss, as indicated by the coding structure that allows for additional units of grafting based on surface area, specifically for adults and the percentage of total body surface area (TBSA) for infants and children.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The tissue cultured skin autograft procedure is indicated for patients requiring coverage of skin defects in specific anatomical regions. The following conditions may warrant this procedure:

  • Facial Defects Coverage of skin loss or damage on the face due to trauma, surgical excision, or disease.
  • Scalp Injuries Treatment of significant scalp wounds or defects resulting from injury or surgical procedures.
  • Eyelid Reconstruction Repair of eyelid defects that may affect vision or cosmetic appearance.
  • Oral Cavity Defects Coverage of wounds or defects in the mouth area, which may arise from trauma or surgical interventions.
  • Neck and Ear Injuries Management of skin loss in the neck and ear regions due to various causes, including burns or surgical removal of lesions.
  • Genitalia Coverage Treatment of defects in the genital area resulting from trauma, disease, or surgical procedures.
  • Hand and Foot Defects Coverage of skin defects on the hands and feet, which may be critical for function and mobility.
  • Multiple Digits Addressing skin loss affecting multiple fingers or toes, which may require specialized grafting techniques.

2. Procedure

The procedure for tissue cultured skin autograft involves several critical steps to ensure successful grafting. The first step is the harvesting of epidermal tissue from the patient, which is typically performed in a separate procedure. This harvested tissue is then sent to a specialized laboratory where it undergoes processing. In the lab, the epidermal cells are separated from the dermal cells and cultured in an incubator. This incubation allows the keratinocytes to proliferate and form sheets of skin, which are essential for the grafting process. Once the cultured grafts are ready, they are placed in a transport medium to maintain their viability during transit back to the surgical facility. Upon arrival at the facility, the physician prepares the recipient site by ensuring that the wound bed is clean and suitable for graft placement. The physician then carefully removes the graft from the transport medium and positions it over the prepared wound bed. To secure the graft in place, the physician may use interrupted sutures around the periphery of the graft. Alternatively, other fixation methods such as staples or fibrin sealant may be utilized, depending on the specific requirements of the procedure and the preferences of the surgical team. This meticulous approach is essential for promoting graft adherence and optimizing healing outcomes.

3. Post-Procedure

After the tissue cultured skin autograft procedure, patients typically require careful monitoring and follow-up care to ensure proper healing of the graft. Post-procedure care may include instructions on wound care, which involves keeping the graft site clean and protected from infection. Patients may be advised to avoid strenuous activities that could disrupt the graft during the initial healing phase. Follow-up appointments are essential to assess the graft's integration with the surrounding tissue and to address any complications that may arise, such as infection or graft failure. The expected recovery time can vary based on the size of the graft and the individual patient's healing response, but ongoing evaluation is crucial to ensure optimal outcomes.

Short Descr TIS CLT AGRFT F/S/N/H/F/G EA
Medium Descr TIS CLTR SKN AGRFT F/S/N/H/F/G/M/DGT EACH ADDL
Long Descr Tissue cultured skin autograft, face, scalp, eyelids, mouth, neck, ears, orbits, genitalia, hands, feet, and/or multiple digits; each additional 100 sq cm, or each additional 1% of body area of infants and children, or part thereof (List separately in addition to code for primary procedure)
Status Code Active Code
Global Days ZZZ - Code Related to Another Service
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 0 - No payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 1 - Statutory payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 1 - Co-surgeons could be paid, though supporting documentation is required...
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Items and Services Packaged into APC Rates
ASC Payment Indicator Packaged service/item; no separate payment made.
Type of Service (TOS) 2 - Surgery
Berenson-Eggers TOS (BETOS) P1G - Major procedure - Other
MUE 1
CCS Clinical Classification 172 - Skin graft

This is an add-on code that must be used in conjunction with one of these primary codes.

15156 Add-on Code MPFS Status: Active Code APC N ASC N1 CPT Assistant Article Tissue cultured skin autograft, face, scalp, eyelids, mouth, neck, ears, orbits, genitalia, hands, feet, and/or multiple digits; additional 1 sq cm to 75 sq cm (List separately in addition to code for primary procedure)
Date
Action
Notes
2025-01-01 Changed Short and Medium Descriptions changed.
2012-01-01 Changed Description Changed
2007-01-01 Changed Code description changed.
2006-01-01 Added First appearance in code book in 2006.
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Description
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