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Official Description

Removal of phrenic nerve stimulator, including vessel catheterization, all imaging guidance, and interrogation and programming, when performed; system, including pulse generator and lead(s)

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

The procedure described by CPT® Code 33278 involves the removal of a phrenic nerve stimulator system, which is specifically utilized for the treatment of central sleep apnea (CSA). This complex surgical intervention is necessitated by the challenges presented in patients who often have underlying conditions such as heart failure and reduced ejection fraction. The procedure entails the careful extraction of the neurostimulator system, which includes an implantable pulse generator and one or more leads, typically positioned in critical vascular structures like the brachiocephalic or pericardiophrenic vein. Due to the anatomical location of these components, there is a significant risk of vascular or cardiac damage during the removal process. The procedure is performed under general anesthesia to ensure patient comfort and safety. It is important to note that while the removal of the entire system is the focus of this code, there are instances where only a lead or the generator may be removed, although these cases are less common. The removal process requires meticulous attention to detail, as the surgeon must navigate the surrounding tissues and ensure that hemodynamic stability is maintained throughout the procedure.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The removal of a phrenic nerve stimulator system, as described by CPT® Code 33278, is indicated for patients undergoing treatment for central sleep apnea (CSA). The procedure is particularly relevant for individuals who may experience complications or require device removal due to various clinical scenarios, including:

  • Heart Failure Patients with heart failure may require the removal of the stimulator due to deteriorating health conditions or changes in treatment plans.
  • Reduced Ejection Fraction Individuals with reduced ejection fraction may necessitate device removal to mitigate risks associated with their cardiac status.
  • Device Malfunction If the phrenic nerve stimulator is malfunctioning or causing adverse effects, removal may be warranted.
  • Infection In cases where a lead becomes infected, it may require removal to prevent further complications.
  • Pre-therapeutic Considerations The generator may be removed prior to other treatments, such as radiation therapy, to avoid interference with those procedures.

2. Procedure

The procedure for the removal of a phrenic nerve stimulator system involves several critical steps to ensure safety and efficacy. The process begins with the establishment of the position of the pulse generator, which is typically located in a subcutaneous pocket. The surgeon makes an incision to access the implanted device. Once the incision is made, the generator and lead(s) are carefully freed from the surrounding tissue to minimize trauma. The leads are then disconnected from the generator, and any suture collars that hold them in place are also released. To facilitate the removal of the lead(s), a stylet or stiff guidewire is inserted onto the lead under fluoroscopic guidance. Gentle manual traction is applied to assist in the extraction. If the lead proves difficult to remove, a locking stylet may be utilized, and a manual rotational extractor or laser sheath is advanced over the lead to aid in its removal. The standard lead extraction technique is then employed to ensure that the lead(s) and generator device are successfully removed. Throughout the procedure, it is crucial to maintain hemodynamic stability before closing the incision. In cases where only the pulse generator is removed, the abandoned lead(s) are disconnected and left in position. Conversely, if a lead alone is being removed, it is carefully freed from surrounding tissue and disconnected from the generator, following the previously described technique for its extraction.

3. Post-Procedure

After the removal of the phrenic nerve stimulator system, patients are monitored for hemodynamic stability and any potential complications that may arise from the procedure. Post-operative care typically includes pain management and observation for signs of infection or other adverse effects. Patients may be advised on activity restrictions and follow-up appointments to assess recovery and ensure that no further interventions are necessary. The surgical site should be kept clean and dry, and any sutures or dressings should be managed according to the surgeon's instructions. It is essential for healthcare providers to provide thorough post-procedure instructions to facilitate optimal recovery and address any concerns the patient may have.

Short Descr RMVL PHRNC NRV STIM SYS
Medium Descr REMOVAL PHRENIC NERVE STIMULATOR SYSTEM
Long Descr Removal of phrenic nerve stimulator, including vessel catheterization, all imaging guidance, and interrogation and programming, when performed; system, including pulse generator and lead(s)
Status Code Active Code
Global Days 090 - Major Surgery
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 2 - Standard payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 1 - Statutory payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Hospital Part B services paid through a comprehensive APC
ASC Payment Indicator Non office-based surgical procedure added in CY 2008 or later; payment based on OPPS relative payment weight.
Type of Service (TOS) 2 - Surgery
Berenson-Eggers TOS (BETOS) none
MUE 1
51 Multiple procedures: when multiple procedures, other than e/m services, physical medicine and rehabilitation services or provision of supplies (eg, vaccines), are performed at the same session by the same individual, the primary procedure or service may be reported as listed. the additional procedure(s) or service(s) may be identified by appending modifier 51 to the additional procedure or service code(s). note: this modifier should not be appended to designated "add-on" codes (see appendix d).
Date
Action
Notes
2024-01-01 Added Code Added.
Code
Description
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