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Allogeneic lymphocyte infusions involve the transfer of lymphocytes from a donor to a recipient, specifically targeting patients who have previously undergone an allogeneic hematopoietic progenitor cell (HPC) transplant. This procedure is particularly relevant for individuals who subsequently develop hematologic malignancies, such as leukemia or lymphoma, after their initial transplant. The term "allogeneic" refers to the use of donor cells, which are derived from a genetically different individual, as opposed to autologous cells that come from the same patient. The process begins with a leukopheresis procedure, which is a separate and reportable intervention performed on the original HPC donor to collect the necessary lymphocytes. Once harvested, these donor lymphocytes can be infused into the recipient either immediately or after being preserved through freezing. The primary goal of this infusion is to elicit a robust graft versus leukemia or lymphoma response, which aims to target and eliminate the malignant cells present in the recipient's body. This therapeutic approach is critical in enhancing the patient's immune response against their cancer, thereby improving their overall prognosis and potential for recovery.
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Allogeneic lymphocyte infusions are indicated for patients who have undergone a prior allogeneic hematopoietic progenitor cell (HPC) transplant and subsequently develop hematologic malignancies. The specific conditions for which this procedure is performed include:
The procedure for allogeneic lymphocyte infusion involves several critical steps to ensure the successful transfer of lymphocytes from the donor to the recipient. These steps include:
Post-procedure care following an allogeneic lymphocyte infusion involves monitoring the recipient for any adverse reactions to the infusion, as well as assessing the effectiveness of the treatment. Patients may require supportive care to manage any side effects that arise, and ongoing evaluation of their hematologic status is essential. The healthcare team will closely observe the patient for signs of graft versus host disease (GVHD) and other complications that may occur as a result of the infusion. Regular follow-up appointments will be necessary to monitor the patient's response to the treatment and to adjust any further therapeutic interventions as needed.
| Short Descr | TRANSPLT ALLO LYMPHOCYTES | Medium Descr | ALLOGENEIC LYMPHOCYTE INFUSIONS | Long Descr | Allogeneic lymphocyte infusions | Status Code | Active Code | Global Days | 000 - Endoscopic or Minor Procedure | PC/TC Indicator (26, TC) | 0 - Physician Service Code | Multiple Procedures (51) | 2 - Standard payment adjustment rules for multiple procedures apply. | Bilateral Surgery (50) | 0 - 150% payment adjustment for bilateral procedures does NOT apply. | Physician Supervisions | 09 - Concept does not apply. | Assistant Surgeon (80, 82) | 0 - Payment restriction for assistants at surgery applies to this procedure... | Co-Surgeons (62) | 0 - Co-surgeons not permitted for this procedure. | Team Surgery (66) | 0 - Team surgeons not permitted for this procedure. | Diagnostic Imaging Family | 99 - Concept Does Not Apply | APC Status Indicator | Procedure or Service, Not Discounted when Multiple | ASC Payment Indicator | Office-based surgical procedure added to ASC list in CY 2008 or later without MPFS nonfacility PE RVUs; payment based on OPPS relative payment weight. | Type of Service (TOS) | 2 - Surgery | Berenson-Eggers TOS (BETOS) | T1H - Lab tests - other (non-Medicare fee schedule) | MUE | 1 | CCS Clinical Classification | 64 - Bone marrow transplant |
| 95 | Synchronous telemedicine service rendered via a real-time interactive audio and video telecommunications system: synchronous telemedicine service is defined as a real-time interaction between a physician or other qualified health care professional and a patient who is located at a distant site from the physician or other qualified health care professional. the totality of the communication of information exchanged between the physician or other qualified health care professional and the patient during the course of the synchronous telemedicine service must be of an amount and nature that would be sufficient to meet the key components and/or requirements of the same service when rendered via a face-to-face interaction. modifier 95 may only be appended to the services listed in appendix p. appendix p is the list of cpt codes for services that are typically performed face-to-face, but may be rendered via a real-time (synchronous) interactive audio and video telecommunications system. | CR | Catastrophe/disaster related | GC | This service has been performed in part by a resident under the direction of a teaching physician | Q0 | Investigational clinical service provided in a clinical research study that is in an approved clinical research study | Q1 | Routine clinical service provided in a clinical research study that is in an approved clinical research study |
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| 2013-01-01 | Changed | Description changed. Guideline information changed. |
| 2003-01-01 | Added | First appearance in code book in 2003. |
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