Coding Ahead
CasePilot
Medical Coding Assistant
CaseConsultant
Instant Email Coding Consultant
Case2Code
Search and Code Lookup Tool
CareerCenter
Medical Coding Job Board
Log in Register free account

Need help choosing the right code?

Ask CasePilot about procedures, modifiers, bundling, and coding guidance.

Try CasePilot

Official Description

Diagnostic bone marrow; aspiration(s)

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

Diagnostic bone marrow aspiration, coded as CPT® 38220, is a medical procedure utilized to obtain samples of bone marrow for the purpose of diagnosing various hematological diseases and cancers. This procedure involves the extraction of liquid bone marrow, which is crucial for evaluating the health and function of the bone marrow, as well as for identifying any abnormalities that may indicate disease. The aspiration can be performed at different anatomical sites, with the anterior or posterior iliac crest being the most common locations. In certain cases, such as when dealing with pediatric patients under 18 months, the aspiration may also be performed from the lower leg or the breastbone. The procedure is typically performed prior to any biopsy, should both procedures be indicated, to ensure that the liquid sample is collected first. The technique requires careful navigation to avoid injury to surrounding nerves, and it involves the use of a hollow needle attached to a syringe to extract the marrow. The aspiration process is critical for obtaining sufficient samples for laboratory analysis, which can lead to a definitive diagnosis and guide subsequent treatment options.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

Bone marrow aspiration is indicated for a variety of clinical scenarios, particularly when there is a need to investigate hematological disorders or malignancies. The following conditions may warrant the performance of this procedure:

  • Hematological Diseases Conditions such as anemia, leukopenia, or thrombocytopenia that require further evaluation of bone marrow function.
  • Cancers Suspected or confirmed malignancies, including leukemia, lymphoma, or multiple myeloma, where bone marrow involvement needs to be assessed.
  • Unexplained Blood Disorders Situations where patients present with abnormal blood counts or unexplained symptoms that suggest a bone marrow pathology.

2. Procedure

The procedure for bone marrow aspiration involves several critical steps to ensure the safe and effective collection of bone marrow samples. The following outlines the procedural steps:

  • Step 1: Patient Preparation The patient is positioned comfortably, and the site of aspiration, typically the anterior or posterior iliac crest, is identified and cleaned with an antiseptic solution to minimize the risk of infection.
  • Step 2: Anesthesia Local anesthesia is administered to numb the area where the needle will be inserted, ensuring the patient experiences minimal discomfort during the procedure.
  • Step 3: Needle Insertion A small incision is made in the skin, and a hollow needle attached to a syringe is carefully advanced approximately 4-5 cm into the bone marrow space. The clinician must take care to avoid the lateral femoral cutaneous nerve when accessing the anterior iliac crest or the cluneal nerves when accessing the posterior iliac crest.
  • Step 4: Aspiration Once the needle is in place, the clinician pulls back on the plunger of the syringe to aspirate a sample of liquid bone marrow. If no sample is obtained, the needle may be repositioned, and multiple samples can be taken as necessary.
  • Step 5: Biopsy (if indicated) If a biopsy is also required, a larger needle is used to obtain a cylindrical core sample of solid bone marrow tissue. This may be done through the same incision or a new one, and the site is then bandaged appropriately.

3. Post-Procedure

After the bone marrow aspiration procedure, patients are typically monitored for any immediate complications, such as bleeding or infection at the site of aspiration. It is common for patients to experience some soreness or discomfort in the area for a few days following the procedure. Instructions for post-procedure care may include keeping the site clean and dry, avoiding strenuous activities for a short period, and monitoring for any signs of complications. Follow-up appointments may be scheduled to discuss the results of the bone marrow analysis and to determine any further necessary interventions based on the findings.

Short Descr DX BONE MARROW ASPIRATIONS
Medium Descr DIAGNOSTIC BONE MARROW ASPIRATIONS
Long Descr Diagnostic bone marrow; aspiration(s)
Status Code Active Code
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 2 - Standard payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 1 - 150% payment adjustment for bilateral procedures applies.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 0 - Payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Hospital Part B services paid through a comprehensive APC
ASC Payment Indicator Office-based surgical procedure added to ASC list in CY 2008 or later with MPFS nonfacility PE RVUs; payment based on MPFS nonfacility PE RVUs.
Type of Service (TOS) 2 - Surgery
Berenson-Eggers TOS (BETOS) P6C - Minor procedures - other (Medicare fee schedule)
MUE 1
CCS Clinical Classification 65 - Bone marrow biopsy

This is a primary code that can be used with these additional add-on codes.

77002 CPT Add On MPFS Status: Active Code APC N ASC N1 Physician Quality Reporting CPT Assistant Article Fluoroscopic guidance for needle placement (eg, biopsy, aspiration, injection, localization device) (List separately in addition to code for primary procedure)
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
51 Multiple procedures: when multiple procedures, other than e/m services, physical medicine and rehabilitation services or provision of supplies (eg, vaccines), are performed at the same session by the same individual, the primary procedure or service may be reported as listed. the additional procedure(s) or service(s) may be identified by appending modifier 51 to the additional procedure or service code(s). note: this modifier should not be appended to designated "add-on" codes (see appendix d).
Q1 Routine clinical service provided in a clinical research study that is in an approved clinical research study
XU Unusual non-overlapping service, the use of a service that is distinct because it does not overlap usual components of the main service
XS Separate structure, a service that is distinct because it was performed on a separate organ/structure
RT Right side (used to identify procedures performed on the right side of the body)
GC This service has been performed in part by a resident under the direction of a teaching physician
LT Left side (used to identify procedures performed on the left side of the body)
AS Physician assistant, nurse practitioner, or clinical nurse specialist services for assistant at surgery
50 Bilateral procedure: unless otherwise identified in the listings, bilateral procedures that are performed at the same session, should be identified by adding modifier 50 to the appropriate 5 digit code. note: this modifier should not be appended to designated "add-on" codes (see appendix d).
52 Reduced services: under certain circumstances a service or procedure is partially reduced or eliminated at the discretion of the physician or other qualified health care professional. under these circumstances the service provided can be identified by its usual procedure number and the addition of modifier 52, signifying that the service is reduced. this provides a means of reporting reduced services without disturbing the identification of the basic service. note: for hospital outpatient reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well-being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
53 Discontinued procedure: under certain circumstances, the physician or other qualified health care professional may elect to terminate a surgical or diagnostic procedure. due to extenuating circumstances or those that threaten the well being of the patient, it may be necessary to indicate that a surgical or diagnostic procedure was started but discontinued. this circumstance may be reported by adding modifier 53 to the code reported by the individual for the discontinued procedure. note: this modifier is not used to report the elective cancellation of a procedure prior to the patient's anesthesia induction and/or surgical preparation in the operating suite. for outpatient hospital/ambulatory surgery center (asc) reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
58 Staged or related procedure or service by the same physician or other qualified health care professional during the postoperative period: it may be necessary to indicate that the performance of a procedure or service during the postoperative period was: (a) planned or anticipated (staged); (b) more extensive than the original procedure; or (c) for therapy following a surgical procedure. this circumstance may be reported by adding modifier 58 to the staged or related procedure. note: for treatment of a problem that requires a return to the operating/procedure room (eg, unanticipated clinical condition), see modifier 78.
78 Unplanned return to the operating/procedure room by the same physician or other qualified health care professional following initial procedure for a related procedure during the postoperative period: it may be necessary to indicate that another procedure was performed during the postoperative period of the initial procedure (unplanned procedure following initial procedure). when this procedure is related to the first, and requires the use of an operating/procedure room, it may be reported by adding modifier 78 to the related procedure. (for repeat procedures, see modifier 76.)
79 Unrelated procedure or service by the same physician or other qualified health care professional during the postoperative period: the individual may need to indicate that the performance of a procedure or service during the postoperative period was unrelated to the original procedure. this circumstance may be reported by using modifier 79. (for repeat procedures on the same day, see modifier 76.)
80 Assistant surgeon: surgical assistant services may be identified by adding modifier 80 to the usual procedure number(s).
82 Assistant surgeon (when qualified resident surgeon not available): the unavailability of a qualified resident surgeon is a prerequisite for use of modifier 82 appended to the usual procedure code number(s).
95 Synchronous telemedicine service rendered via a real-time interactive audio and video telecommunications system: synchronous telemedicine service is defined as a real-time interaction between a physician or other qualified health care professional and a patient who is located at a distant site from the physician or other qualified health care professional. the totality of the communication of information exchanged between the physician or other qualified health care professional and the patient during the course of the synchronous telemedicine service must be of an amount and nature that would be sufficient to meet the key components and/or requirements of the same service when rendered via a face-to-face interaction. modifier 95 may only be appended to the services listed in appendix p. appendix p is the list of cpt codes for services that are typically performed face-to-face, but may be rendered via a real-time (synchronous) interactive audio and video telecommunications system.
AG Primary physician
AQ Physician providing a service in an unlisted health professional shortage area (hpsa)
CC Procedure code change (use 'cc' when the procedure code submitted was changed either for administrative reasons or because an incorrect code was filed)
CR Catastrophe/disaster related
ET Emergency services
GV Attending physician not employed or paid under arrangement by the patient's hospice provider
GW Service not related to the hospice patient's terminal condition
Q6 Service furnished under a fee-for-time compensation arrangement by a substitute physician or by a substitute physical therapist furnishing outpatient physical therapy services in a health professional shortage area, a medically underserved area, or a rural area
SA Nurse practitioner rendering service in collaboration with a physician
SG Ambulatory surgical center (asc) facility service
T5 Right foot, great toe
TA Left foot, great toe
X4 Episodic/focused services: for reporting services by clinicians who provide focused care on particular types of treatment limited to a defined period and circumstance; the patient has a problem, acute or chronic, that will be treated with surgery, radiation, or some other type of generally time-limited intervention; reporting clinician service examples include but are not limited to, the orthopedic surgeon performing a knee replacement and seeing the patient through the postoperative period
X5 Diagnostic services requested by another clinician: for reporting services by a clinician who furnishes care to the patient only as requested by another clinician or subsequent and related services requested by another clinician; this modifier is reported for patient relationships that may not be adequately captured by the above alternative categories; reporting clinician service examples include but are not limited to, the radiologist's interpretation of an imaging study requested by another clinician
XE Separate encounter, a service that is distinct because it occurred during a separate encounter
Date
Action
Notes
2018-01-01 Changed Long, medium and short descriptions changed. AMA guidelines changed.
2013-01-01 Changed Guideline information changed.
2003-01-01 Changed Code description changed.
2002-01-01 Added Added.
Code
Description
Code
Description
Code
Description
Code
Description
Code
Description
CasePilot

Get instant expert-level medical coding assistance.

Ask about:
CPT Codes Guidelines Modifiers Crosswalks NCCI Edits Compliance Medicare Coverage
Example: "What is CPT code 99213?" or "Guidelines for E/M services"