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Official Description

Keratoplasty (corneal transplant); penetrating (except in aphakia or pseudophakia)

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

Keratoplasty, specifically the procedure denoted by CPT® Code 65730, refers to a penetrating corneal transplant that is performed to replace a damaged or diseased cornea with a healthy donor cornea. This full-thickness transplant is indicated for various ocular conditions, including viral keratitis, keratoconus, Fuchs' endothelial dystrophy, bullous keratopathy, and corneal scarring or dystrophy resulting from trauma or keratitis. Prior to the surgical intervention, the patient's eyes are miosed, which means that the pupils are constricted to minimize the risk of lens damage and to prevent the development of cataracts during the procedure. The surgical technique involves trephination, where the recipient's cornea is cut using a manual, motorized, or vacuum trephine. Initially, a partial-thickness trephination is performed to avoid rapid decompression of the eye, followed by a full-thickness cut to excise the damaged cornea. The size of the donor graft is carefully determined, with the donor corneoscleral graft button being cut to be 0.5 mm larger than the recipient bed, ensuring a proper fit. The donor button is then secured in place using either radially interrupted sutures at the 12, 3, 6, and 9 o'clock positions or a single continuous running suture. Finally, to restore the volume in the anterior chamber, a balanced salt solution is injected, completing the procedure.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The procedure of penetrating keratoplasty (CPT® Code 65730) is indicated for a variety of ocular conditions that compromise the integrity and function of the cornea. These indications include:

  • Viral Keratitis - An infection of the cornea caused by a virus, leading to inflammation and potential scarring.
  • Keratoconus - A progressive thinning and bulging of the cornea, resulting in distorted vision.
  • Fuchs' Endothelial Dystrophy - A genetic condition affecting the corneal endothelium, leading to corneal swelling and vision loss.
  • Bullous Keratopathy - A condition characterized by the formation of blisters on the cornea due to endothelial dysfunction.
  • Corneal Scarring - Scarring of the cornea due to trauma, infection, or other diseases that impair vision.
  • Dystrophy - Various forms of corneal dystrophies that can lead to visual impairment and may necessitate transplantation.

2. Procedure

The procedure for penetrating keratoplasty involves several critical steps to ensure successful transplantation of the cornea. The steps are as follows:

  • Step 1: Miosis Induction - Prior to the surgical procedure, miosis is induced in the patient's eyes to constrict the pupils. This is a precautionary measure to protect the lens from potential damage during the surgery and to minimize the risk of cataract formation.
  • Step 2: Trephination of the Recipient Cornea - The surgeon performs trephination on the recipient's cornea using a manual, motorized, or vacuum trephine. Initially, a partial-thickness trephination cut is made to prevent rapid decompression of the eye, followed by a full-thickness cut to excise the damaged cornea.
  • Step 3: Graft Sizing - The size of the donor graft is determined based on the dimensions of the recipient bed. The donor corneoscleral graft button is cut with the epithelial side facing up in a concave setting, ensuring it is 0.5 mm larger than the recipient bed for a proper fit.
  • Step 4: Graft Placement - The donor button is then positioned onto the recipient bed. The graft is secured in place using either radially interrupted sutures placed at the 12, 3, 6, and 9 o'clock positions or with a single continuous running suture, depending on the surgeon's preference.
  • Step 5: Anterior Chamber Volume Restoration - To complete the procedure, the volume in the anterior chamber is restored by injecting a balanced salt solution, ensuring that the eye maintains its proper structure and function post-surgery.

3. Post-Procedure

After the penetrating keratoplasty procedure, patients typically require careful monitoring and follow-up care to ensure proper healing and to address any potential complications. Post-operative care may include the use of topical antibiotics to prevent infection, corticosteroids to reduce inflammation, and regular follow-up visits to assess the graft's integration and the overall health of the eye. Patients are advised to avoid strenuous activities and to protect the eye from trauma during the initial recovery period. The expected recovery time can vary, but patients may experience improved vision over several weeks to months as the graft heals and stabilizes.

Short Descr CORNEAL TRANSPLANT
Medium Descr KERATOPLASTY PENTRG EXCEPT APHAKIA/PSEUDOPHAKIA
Long Descr Keratoplasty (corneal transplant); penetrating (except in aphakia or pseudophakia)
Status Code Active Code
Global Days 090 - Major Surgery
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 2 - Standard payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 1 - 150% payment adjustment for bilateral procedures applies.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 2 - Payment restriction for assistants at surgery does not apply to this procedure...
Co-Surgeons (62) 1 - Co-surgeons could be paid, though supporting documentation is required...
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Hospital Part B services paid through a comprehensive APC
ASC Payment Indicator Surgical procedure on ASC list in CY 2007; payment based on OPPS relative payment weight.
Type of Service (TOS) 2 - Surgery
Berenson-Eggers TOS (BETOS) P4A - Eye procedure - corneal transplant
MUE 1
CCS Clinical Classification 13 - Corneal transplant
LT Left side (used to identify procedures performed on the left side of the body)
RT Right side (used to identify procedures performed on the right side of the body)
22 Increased procedural services: when the work required to provide a service is substantially greater than typically required, it may be identified by adding modifier 22 to the usual procedure code. documentation must support the substantial additional work and the reason for the additional work (ie, increased intensity, time, technical difficulty of procedure, severity of patient's condition, physical and mental effort required). note: this modifier should not be appended to an e/m service.
50 Bilateral procedure: unless otherwise identified in the listings, bilateral procedures that are performed at the same session, should be identified by adding modifier 50 to the appropriate 5 digit code. note: this modifier should not be appended to designated "add-on" codes (see appendix d).
51 Multiple procedures: when multiple procedures, other than e/m services, physical medicine and rehabilitation services or provision of supplies (eg, vaccines), are performed at the same session by the same individual, the primary procedure or service may be reported as listed. the additional procedure(s) or service(s) may be identified by appending modifier 51 to the additional procedure or service code(s). note: this modifier should not be appended to designated "add-on" codes (see appendix d).
52 Reduced services: under certain circumstances a service or procedure is partially reduced or eliminated at the discretion of the physician or other qualified health care professional. under these circumstances the service provided can be identified by its usual procedure number and the addition of modifier 52, signifying that the service is reduced. this provides a means of reporting reduced services without disturbing the identification of the basic service. note: for hospital outpatient reporting of a previously scheduled procedure/service that is partially reduced or cancelled as a result of extenuating circumstances or those that threaten the well-being of the patient prior to or after administration of anesthesia, see modifiers 73 and 74 (see modifiers approved for asc hospital outpatient use).
54 Surgical care only: when 1 physician or other qualified health care professional performs a surgical procedure and another provides preoperative and/or postoperative management, surgical services may be identified by adding modifier 54 to the usual procedure number.
55 Postoperative management only: when 1 physician or other qualified health care professional performed the postoperative management and another performed the surgical procedure, the postoperative component may be identified by adding modifier 55 to the usual procedure number.
58 Staged or related procedure or service by the same physician or other qualified health care professional during the postoperative period: it may be necessary to indicate that the performance of a procedure or service during the postoperative period was: (a) planned or anticipated (staged); (b) more extensive than the original procedure; or (c) for therapy following a surgical procedure. this circumstance may be reported by adding modifier 58 to the staged or related procedure. note: for treatment of a problem that requires a return to the operating/procedure room (eg, unanticipated clinical condition), see modifier 78.
59 Distinct procedural service: under certain circumstances, it may be necessary to indicate that a procedure or service was distinct or independent from other non-e/m services performed on the same day. modifier 59 is used to identify procedures/services, other than e/m services, that are not normally reported together, but are appropriate under the circumstances. documentation must support a different session, different procedure or surgery, different site or organ system, separate incision/excision, separate lesion, or separate injury (or area of injury in extensive injuries) not ordinarily encountered or performed on the same day by the same individual. however, when another already established modifier is appropriate it should be used rather than modifier 59. only if no more descriptive modifier is available, and the use of modifier 59 best explains the circumstances, should modifier 59 be used. note: modifier 59 should not be appended to an e/m service. to report a separate and distinct e/m service with a non-e/m service performed on the same date, see modifier 25.
62 Two surgeons: when 2 surgeons work together as primary surgeons performing distinct part(s) of a procedure, each surgeon should report his/her distinct operative work by adding modifier 62 to the procedure code and any associated add-on code(s) for that procedure as long as both surgeons continue to work together as primary surgeons. each surgeon should report the co-surgery once using the same procedure code. if additional procedure(s) (including add-on procedure(s) are performed during the same surgical session, separate code(s) may also be reported with modifier 62 added. note: if a co-surgeon acts as an assistant in the performance of additional procedure(s), other than those reported with the modifier 62, during the same surgical session, those services may be reported using separate procedure code(s) with modifier 80 or modifier 82 added, as appropriate.
74 Discontinued out-patient hospital/ambulatory surgery center (asc) procedure after administration of anesthesia: due to extenuating circumstances or those that threaten the well being of the patient, the physician may terminate a surgical or diagnostic procedure after the administration of anesthesia (local, regional block(s), general) or after the procedure was started (incision made, intubation started, scope inserted, etc). under these circumstances, the procedure started but terminated can be reported by its usual procedure number and the addition of modifier 74. note: the elective cancellation of a service prior to the administration of anesthesia and/or surgical preparation of the patient should not be reported. for physician reporting of a discontinued procedure, see modifier 53.
76 Repeat procedure or service by same physician or other qualified health care professional: it may be necessary to indicate that a procedure or service was repeated by the same physician or other qualified health care professional subsequent to the original procedure or service. this circumstance may be reported by adding modifier 76 to the repeated procedure or service. note: this modifier should not be appended to an e/m service.
78 Unplanned return to the operating/procedure room by the same physician or other qualified health care professional following initial procedure for a related procedure during the postoperative period: it may be necessary to indicate that another procedure was performed during the postoperative period of the initial procedure (unplanned procedure following initial procedure). when this procedure is related to the first, and requires the use of an operating/procedure room, it may be reported by adding modifier 78 to the related procedure. (for repeat procedures, see modifier 76.)
79 Unrelated procedure or service by the same physician or other qualified health care professional during the postoperative period: the individual may need to indicate that the performance of a procedure or service during the postoperative period was unrelated to the original procedure. this circumstance may be reported by using modifier 79. (for repeat procedures on the same day, see modifier 76.)
80 Assistant surgeon: surgical assistant services may be identified by adding modifier 80 to the usual procedure number(s).
82 Assistant surgeon (when qualified resident surgeon not available): the unavailability of a qualified resident surgeon is a prerequisite for use of modifier 82 appended to the usual procedure code number(s).
AS Physician assistant, nurse practitioner, or clinical nurse specialist services for assistant at surgery
CR Catastrophe/disaster related
GC This service has been performed in part by a resident under the direction of a teaching physician
GW Service not related to the hospice patient's terminal condition
SG Ambulatory surgical center (asc) facility service
Date
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2009-01-01 Changed Code description changed
Pre-1990 Added Code added.
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