How To Use CPT Code 0183U

CPT 0183U describes a specific gene analysis test called Red cell antigen (Diego blood group) genotyping (DI), gene analysis, SLC4A1 (solute carrier family 4 member 1 [Diego blood group]) exon 19. This article will cover the official description, procedure, qualifying circumstances, appropriate usage, documentation requirements, billing guidelines, historical information, and examples of CPT code 0183U.

1. What is CPT Code 0183U?

CPT 0183U is a proprietary laboratory analysis (PLA) code that represents the Navigator DI Sequencing test from Grifols Immunohematology Center. This test analyzes the SLC4A1 gene’s exon 19 to determine the presence of Diego (DI) blood group antigens. The test helps clinicians minimize adverse blood-type incompatibility reactions in blood transfusions, organ transplants, and pregnancy and newborns.

2. Official Description

The official description of CPT code 0183U is: ‘Red cell antigen (Diego blood group) genotyping (DI), gene analysis, SLC4A1 (solute carrier family 4 member 1 [Diego blood group]) exon 19.’

3. Procedure

1. The lab analyst performs gene analysis using a patient specimen, such as blood or saliva, to analyze exon 19 of the SLC4A1 gene.
2. The test involves DNA amplification, typically using polymerase chain reaction (PCR), to make multiple copies of the desired gene for study.
3. A Luminex® platform is used to identify genetic markers for specific red blood cell antigens in the Diego blood group.
4. The test helps determine the presence of allele(s) that determine red blood cell antigens, which are crucial for blood group compatibility.
5. The analysis provides valuable information for clinicians to improve transfusion or transplant compatibility and minimize adverse reactions in pregnancy and newborns.

4. Qualifying circumstances

CPT code 0183U is ordered for various circumstances, including:

• Testing specimens from blood or tissue donors and recipients to improve transfusion or transplant compatibility.
• Testing maternal blood to minimize adverse blood reactions or maternal antibody formation in newborns.
• Diagnosing hereditary ovalocytosis, a disease involving oval-shaped red blood cells.
• Diagnosing hemolytic disease of the newborn (HDN) due to maternal antibodies attacking fetal cells.

5. When to use CPT code 0183U

CPT code 0183U should be used when ordering the Navigator DI Sequencing test from Grifols Immunohematology Center to analyze exon 19 of the SLC4A1 gene. It should not be used for any other test or purpose.

6. Documentation requirements

To support a claim for CPT code 0183U, the following documentation is required:

• Indication for the test, including the reason for ordering the Navigator DI Sequencing test.
• Specimen type used for analysis, such as blood or saliva.
• Date of service when the test was performed.
• Results of the gene analysis, specifically related to exon 19 of the SLC4A1 gene.
• Signature of the lab analyst who performed the test.

7. Billing guidelines

When billing for CPT code 0183U, ensure that the test is performed by Grifols Immunohematology Center using the Navigator DI Sequencing test. Report one unit of this code for a single specimen analyzed on a single date of service. Some payers may separately reimburse for specimen collection using a code like 36415. It is important to use the correct code for the specific blood group antigen genotype analysis, as Grifols Immunohematology Center provides multiple PLA codes for different blood group antigens.

8. Historical information

CPT code 0183U was added to the Current Procedural Terminology system on July 1, 2020. There have been no updates or changes to the code since its addition.

9. Examples

1. A clinician orders CPT code 0183U to analyze the SLC4A1 gene’s exon 19 in a blood sample from a patient undergoing a kidney transplant to ensure compatibility.
2. A laboratory performs the Navigator DI Sequencing test using CPT code 0183U on a specimen from a pregnant woman to assess the risk of adverse blood reactions in her newborn.
3. A patient with a family history of hereditary ovalocytosis undergoes the Navigator DI Sequencing test using CPT code 0183U to confirm the presence of the disease.
4. A neonatal intensive care unit orders CPT code 0183U to analyze the SLC4A1 gene’s exon 19 in a newborn’s blood sample to diagnose hemolytic disease due to maternal antibodies.
5. A clinician requests CPT code 0183U for a patient with anemia to determine the presence of Diego blood group antigens and guide transfusion therapy.
6. A laboratory performs the Navigator DI Sequencing test using CPT code 0183U on a specimen from a potential blood donor to assess compatibility with potential recipients.
7. A clinician orders CPT code 0183U to analyze the SLC4A1 gene’s exon 19 in a blood sample from a patient with a history of adverse blood reactions to identify potential antigen incompatibility.
8. A laboratory uses CPT code 0183U to analyze the SLC4A1 gene’s exon 19 in a specimen from a patient with suspected hereditary ovalocytosis to confirm the diagnosis.
9. A clinician orders CPT code 0183U for a patient with a history of hemolytic disease of the newborn to assess the risk of recurrence in future pregnancies.
10. A laboratory performs the Navigator DI Sequencing test using CPT code 0183U on a specimen from a patient with an unknown blood type to determine the presence of Diego blood group antigens.