How To Use CPT Code 0201U

CPT 0201U describes a specific gene analysis test known as Red cell antigen (Yt blood group) genotyping (YT), gene analysis, ACHE (acetylcholinesterase [Cartwright blood group]) exon 2. This article will cover the official description, procedure, qualifying circumstances, appropriate usage, documentation requirements, billing guidelines, historical information, and examples of CPT code 0201U.

1. What is CPT Code 0201U?

CPT 0201U is a proprietary laboratory analysis code that applies to a unique lab test called Navigator YT Sequencing. This test is performed by Grifols Immunohematology Center using a specimen such as blood. The analysis focuses on specific gene sequences related to YT blood group antigens. The purpose of this test is to help clinicians minimize adverse blood-type incompatibility reactions in situations such as blood transfusions, organ transplants, or during pregnancy and newborn care.

2. Official Description

The official description of CPT code 0201U is: ‘Red cell antigen (Yt blood group) genotyping (YT), gene analysis, ACHE (acetylcholinesterase [Cartwright blood group]) exon 2.’

3. Procedure

1. The lab analyst performs gene analysis using a patient specimen, such as blood or saliva, to analyze exon 2 of the ACHE gene.
2. The ACHE gene variation determines the individual’s YT blood group, also known as Cartwright, by identifying the presence or absence of specific YT red blood cell (RBC) antigens.
3. The test involves DNA amplification using methods like polymerase chain reaction (PCR) and utilizes a Luminex® platform to identify genetic markers for specific red blood cell antigens in the YT blood group.

4. Qualifying circumstances

CPT code 0201U is ordered for specimens from blood or tissue donors and recipients to improve transfusion or transplant compatibility. It can also be ordered for maternal blood specimens to minimize adverse blood reactions in newborns or maternal antibody formation. This test helps determine the presence or absence of specific YT red blood cell antigens, providing advantages over traditional serology typing methods.

5. When to use CPT code 0201U

CPT code 0201U should be used when the Navigator YT Sequencing test is performed to analyze the ACHE gene and determine the individual’s YT blood group antigens. It should not be used for any other purpose or test.

6. Documentation requirements

To support a claim for CPT code 0201U, the following documentation is required:

• Indication of the need for the test
• Specific gene analysis performed, including ACHE exon 2
• Date of service
• Signature of the lab analyst performing the test

7. Billing guidelines

When billing for CPT code 0201U, ensure that the test is performed by Grifols Immunohematology Center using the Navigator YT Sequencing method. Report one unit of this code for a single specimen analyzed on a single date of service. Some payers may separately reimburse for specimen collection using a code like 36415. It is important to use the correct code for the specific blood group antigen genotype analysis.

8. Historical information

CPT code 0201U was added to the Current Procedural Terminology system on July 1, 2020. There have been no updates or changes to the code since its addition.

9. Examples

1. A patient undergoes the Navigator YT Sequencing test to determine their YT blood group antigens before a scheduled blood transfusion.
2. A pregnant woman’s blood is tested using the Navigator YT Sequencing method to minimize adverse blood reactions in the newborn.
3. A tissue recipient undergoes the Navigator YT Sequencing test to ensure compatibility with the donor’s blood type.
4. A blood donor’s specimen is analyzed using the Navigator YT Sequencing method to determine their YT blood group antigens for better matching during transfusions.
5. A patient with a history of adverse blood reactions during previous transfusions undergoes the Navigator YT Sequencing test to identify potential incompatibilities.
6. A newborn’s blood is tested using the Navigator YT Sequencing method to minimize the risk of adverse reactions due to blood type incompatibility.
7. A patient scheduled for an organ transplant undergoes the Navigator YT Sequencing test to ensure compatibility with the donor’s blood type.
8. A pregnant woman’s blood is analyzed using the Navigator YT Sequencing method to identify potential risks of adverse blood reactions during pregnancy.
9. A patient with a rare blood type undergoes the Navigator YT Sequencing test to determine the presence or absence of specific YT red blood cell antigens.
10. A blood donor’s specimen is tested using the Navigator YT Sequencing method to ensure compatibility with potential recipients.