How To Use CPT Code 80285

CPT 80285 describes the laboratory test used to quantify the level of voriconazole, an antifungal medication, in a patient’s specimen. This article will cover the description, procedure, qualifying circumstances, appropriate usage, documentation requirements, billing guidelines, historical information, similar codes and billing examples.

1. What is CPT Code 80285?

CPT 80285 can be used to describe the laboratory test performed by a lab analyst to measure the level of voriconazole in a patient’s specimen. This test is commonly ordered for patients taking voriconazole to monitor patient compliance, therapeutic levels, and possible toxicity.

2. Official Description

The official description of CPT code 80285 is: ‘Voriconazole, quantification.’

3. Procedure

1. The lab analyst performs all technical steps to measure the level of voriconazole present in the patient’s specimen.
2. The most common specimen used for this test is serum.
3. The lab analyst may use liquid chromatography-tandem mass spectrometry (LC-MS/MS) as the detection method.
4. The specimen is prepared for an automated analytical instrument.
5. The instrument passes the sample through a high-pressure liquid chromatograph to separate components.
6. The components are ionized and transferred to mass spectrometers to provide structural identity and quantification based on mass-to-charge ratio.
7. The instrument provides a quantitative result for voriconazole.

4. Qualifying circumstances

This test is commonly ordered for patients taking voriconazole, an antifungal agent, to monitor patient compliance, therapeutic levels, and possible toxicity. It may be particularly important for patients with CYP2C19 polymorphisms associated with reduced liver function.

5. When to use CPT code 80285

CPT code 80285 should be used when quantifying the level of voriconazole in a patient’s specimen. It is appropriate to bill this code when the test is performed to monitor patient compliance, therapeutic levels, and possible toxicity.

6. Documentation requirements

To support a claim for CPT code 80285, the documentation should include:

• Patient’s information and reason for ordering the test
• Specimen type used for the test
• Details of the test procedure, including the detection method
• Quantitative result for voriconazole

7. Billing guidelines

When billing for CPT code 80285, ensure that the test is performed to quantify the level of voriconazole in the patient’s specimen. It is important to follow the specific guidelines provided by the payer regarding documentation and coding requirements. It is also important to note that some payers may separately reimburse for specimen collection using a different code.

8. Historical information

CPT code 80285 was added to the Current Procedural Terminology system on January 1, 2020. There have been no updates to the code since its addition.

9. Examples

1. A lab analyst performs the test to quantify the level of voriconazole in a patient’s serum specimen to monitor therapeutic levels.
2. The test is ordered for a patient taking voriconazole to ensure patient compliance and detect any potential toxicity.
3. A patient with CYP2C19 polymorphisms associated with reduced liver function undergoes the test to monitor the level of voriconazole in their specimen.
4. The lab analyst performs the test to quantify the level of voriconazole in a patient’s specimen to assess the effectiveness of the antifungal treatment.
5. A clinician orders the test to monitor the voriconazole levels in a patient’s specimen and adjust the dosage accordingly.