How To Use CPT Code 81107

CPT 81107 describes the genetic analysis procedure for Human Platelet Antigen 3 (HPA-3) genotyping. This article will cover the description, procedure, qualifying circumstances, appropriate usage, documentation requirements, billing guidelines, historical information, similar codes and billing examples.

1. What is CPT Code 81107?

CPT 81107 can be used to describe the genetic analysis procedure for Human Platelet Antigen 3 (HPA-3) genotyping. This code is used when a lab analyst performs the technical steps to analyze the genes of the two common alleles of HPA-3, also known as I843S. The analysis is typically done using a specimen such as blood or amniotic fluid.

2. Official Description

The official description of CPT code 81107 is: ‘Human Platelet Antigen 3 genotyping (HPA-3), ITGA2B (integrin, alpha 2b [platelet glycoprotein IIb of IIb/IIIa complex], antigen CD41 [GPIIb]) (eg, neonatal alloimmune thrombocytopenia [NAIT], post-transfusion purpura), gene analysis, common variant, HPA-3a/b (I843S).’

3. Procedure

1. The lab analyst performs the technical steps of the genetic analysis procedure for HPA-3 genotyping.
2. This includes extracting nucleic acids from the specimen, amplifying the genes of interest using methods like polymerase chain reaction (PCR), and detecting the target genes using fluorescence or other markers.
3. The analysis specifically focuses on identifying the two common alleles of HPA-3, HPA-3a and HPA-3b.
4. The procedure may be performed on specimens such as blood or amniotic fluid.

4. Qualifying circumstances

CPT 81107 may be ordered by clinicians to assess risk or aid in the diagnosis of conditions such as neonatal alloimmune thrombocytopenia (NAIT), post-transfusion purpura (PTP), and thrombocytopenia. The test helps identify the patient’s HPA-3 antigen genotype, which can be crucial in assessing the risk of blood-related disorders caused by immune responses to different HPA antigen genotypes.

5. When to use CPT code 81107

CPT code 81107 should be used when a genetic analysis procedure is performed to determine the HPA-3 antigen genotype of a patient. It is commonly ordered in cases where there is a suspected risk of neonatal alloimmune thrombocytopenia (NAIT), post-transfusion purpura (PTP), or thrombocytopenia.

6. Documentation requirements

To support a claim for CPT 81107, documentation should include:

• Reason for ordering the test and the suspected condition
• Details of the technical steps performed by the lab analyst
• Specimen used for the analysis (e.g., blood or amniotic fluid)
• Results of the genetic analysis, including the patient’s HPA-3 antigen genotype
• Signature of the lab analyst performing the procedure

7. Billing guidelines

When billing for CPT 81107, ensure that the procedure is performed by a lab analyst and that the necessary technical steps are followed. It is important to distinguish CPT 81107 from other HPA genotype tests described by different codes in the range 81105-81112. If the ordering clinician requests physician interpretation of the test, an additional code such as G0452 with modifier 26 may be reported.

8. Historical information

CPT 81107 was added to the Current Procedural Terminology system on January 1, 2018. There have been no updates to the code since its addition.

9. Examples

1. A lab analyst performs the genetic analysis procedure for HPA-3 genotyping on a blood specimen to assess the risk of neonatal alloimmune thrombocytopenia (NAIT) in a fetus.
2. Using amniotic fluid, a lab analyst performs the genetic analysis procedure for HPA-3 genotyping to aid in the diagnosis of post-transfusion purpura (PTP) in a patient.
3. A clinician orders the genetic analysis procedure for HPA-3 genotyping on a blood sample to assess the risk of thrombocytopenia in a patient with unexplained bleeding.
4. For a patient with a suspected immune response to blood transfusion, a lab analyst performs the genetic analysis procedure for HPA-3 genotyping on a blood specimen to identify potential HPA antigen incompatibility.
5. A lab analyst performs the genetic analysis procedure for HPA-3 genotyping on a blood sample to assess the risk of neonatal alloimmune thrombocytopenia (NAIT) in a pregnant patient with a history of affected pregnancies.
6. Using a blood specimen, a lab analyst performs the genetic analysis procedure for HPA-3 genotyping to aid in the diagnosis of post-transfusion purpura (PTP) in a patient with a recent blood transfusion.
7. A clinician orders the genetic analysis procedure for HPA-3 genotyping on a blood sample to assess the risk of thrombocytopenia in a patient with a family history of blood-related disorders.
8. For a patient with a suspected immune response to blood transfusion, a lab analyst performs the genetic analysis procedure for HPA-3 genotyping on a blood specimen to identify potential HPA antigen incompatibility.