How To Use CPT Code 81410

CPT 81410 describes the genomic sequence analysis panel used to evaluate patients with aortic dysfunction or dilation. This article will cover the description, procedure, qualifying circumstances, appropriate usage, documentation requirements, billing guidelines, historical information, similar codes and billing examples.

1. What is CPT Code 81410?

CPT 81410 can be used to describe the genomic sequence analysis panel performed by a lab analyst to evaluate patients with aortic dysfunction or dilation. This code is used when the analyst performs sequencing of at least nine specific genes, including FBN1, TGFBR1, TGFBR2, COL3A1, MYH11, ACTA2, SLC2A10, SMAD3, and MYLK, to identify genetic sequences related to these conditions.

2. Official Description

The official description of CPT code 81410 is: ‘Aortic dysfunction or dilation (eg, Marfan syndrome, Loeys Dietz syndrome, Ehler Danlos syndrome type IV, arterial tortuosity syndrome); genomic sequence analysis panel, must include sequencing of at least 9 genes, including FBN1, TGFBR1, TGFBR2, COL3A1, MYH11, ACTA2, SLC2A10, SMAD3, and MYLK.’

3. Procedure

1. The lab analyst collects a patient specimen, such as blood, for the genomic sequence analysis panel.
2. Using specialized equipment, such as a next-generation gene sequencer, the analyst performs a genomic sequence analysis of at least nine specific genes listed in the code descriptor.
3. The instrument generates a sequence read, which is compared to a reference genome to identify any variants or abnormalities in the genes associated with aortic dysfunction or dilation.
4. The results of the analysis help in the diagnosis and differentiation of various genetic disorders, such as Marfan syndrome, Loeys Dietz syndrome, Ehler Danlos syndrome type IV, and arterial tortuosity syndrome.
5. The procedure provides valuable information for clinicians to determine appropriate treatment and management strategies for patients with aortic dysfunction or dilation.

4. Qualifying circumstances

CPT 81410 is used for patients suspected of having aortic dysfunction or dilation, including conditions such as Marfan syndrome, Loeys Dietz syndrome, Ehler Danlos syndrome type IV, and arterial tortuosity syndrome. The genomic sequence analysis panel must include sequencing of at least nine specific genes, including FBN1, TGFBR1, TGFBR2, COL3A1, MYH11, ACTA2, SLC2A10, SMAD3, and MYLK. This analysis helps in identifying genetic variants associated with these conditions and aids in their diagnosis and management.

5. When to use CPT code 81410

CPT code 81410 should be used when a genomic sequence analysis panel is performed to evaluate patients suspected of having aortic dysfunction or dilation. It is appropriate to use this code when sequencing of at least nine specific genes, as listed in the code descriptor, is included in the analysis. This code should not be used for other types of genetic testing or when sequencing of fewer than nine genes is performed.

6. Documentation requirements

To support a claim for CPT 81410, the documentation should include:

• Indication for the genomic sequence analysis panel
• Specific genes sequenced, including FBN1, TGFBR1, TGFBR2, COL3A1, MYH11, ACTA2, SLC2A10, SMAD3, and MYLK
• Date of the analysis
• Results of the analysis, including any identified variants or abnormalities
• Signature of the lab analyst performing the analysis

7. Billing guidelines

When billing for CPT 81410, ensure that the genomic sequence analysis panel includes sequencing of at least nine specific genes, as listed in the code descriptor. It is important to distinguish between CPT 81410 and CPT 81411, which is used for a different type of analysis panel. Report both codes if both analyses are performed. Additionally, be aware that some payers may separately reimburse for specimen collection using a code such as 36415.

8. Historical information

CPT 81410 was added to the Current Procedural Terminology system on January 1, 2015. There have been no updates to the code since its addition.

9. Examples

1. A lab analyst performs a genomic sequence analysis panel for a patient suspected of having Marfan syndrome, sequencing the genes FBN1, TGFBR1, TGFBR2, COL3A1, MYH11, ACTA2, SLC2A10, SMAD3, and MYLK.
2. A patient with aortic dysfunction undergoes a genomic sequence analysis panel, which includes sequencing of the genes FBN1, TGFBR1, TGFBR2, COL3A1, MYH11, ACTA2, SLC2A10, SMAD3, and MYLK, to aid in the diagnosis of their condition.