How To Use CPT Code 81432
CPT 81432 describes the genomic sequence analysis panel for hereditary breast cancer-related disorders. This article will cover the description, procedure, qualifying circumstances, appropriate usage, documentation requirements, billing guidelines, historical information, similar codes and billing examples.
1. What is CPT Code 81432?
CPT 81432 can be used to describe the genomic sequence analysis panel for hereditary breast cancer-related disorders. This code is used when a lab analyst performs a genetic test to evaluate the patient specimen for genetic sequences of at least 10 genes, including BRCA1, BRCA2, CDH1, MLH1, MSH2, MSH6, PALB2, PTEN, STK11, and TP53. The test involves using specialized equipment to determine the order of nucleotides in DNA and comparing the results to a reference genome.
2. Official Description
The official description of CPT code 81432 is: ‘Hereditary breast cancer-related disorders (eg, hereditary breast cancer, hereditary ovarian cancer, hereditary endometrial cancer); genomic sequence analysis panel, must include sequencing of at least 10 genes, always including BRCA1, BRCA2, CDH1, MLH1, MSH2, MSH6, PALB2, PTEN, STK11, and TP53.’
3. Procedure
- The lab analyst collects a patient specimen, such as blood, for the genomic sequence analysis panel.
- Using specialized equipment, such as a next-generation gene sequencer, the lab analyst performs a genomic sequence analysis of at least 10 genes, including BRCA1, BRCA2, CDH1, MLH1, MSH2, MSH6, PALB2, PTEN, STK11, and TP53.
- The instrument reports the sequence as a string of letters, called a read, which the analyst compares to a reference genome of the same genes to identify any variants or alterations.
- The test results help clinicians evaluate patients for susceptibility to hereditary breast cancer-related disorders and guide genetic counseling and management decisions.
