How To Use CPT Code 0087U

CPT 0087U describes the mRNA gene expression profiling by microarray of 1283 genes in transplant biopsy tissue for the purpose of assessing allograft rejection and injury. This article will cover the official description, procedure, qualifying circumstances, appropriate usage, documentation requirements, billing guidelines, historical information, and examples of CPT code 0087U.

1. What is CPT Code 0087U?

CPT 0087U can be used to describe the mRNA gene expression profiling by microarray of 1283 genes in transplant biopsy tissue. This test is specifically designed to determine the probability score of allograft rejection and injury in heart transplant patients. It analyzes the mRNA levels in the biopsy tissue and compares the results to a reference library to identify the reason for transplant organ failure.

2. Official Description

The official description of CPT code 0087U is: ‘Cardiology (heart transplant), mRNA gene expression profiling by microarray of 1283 genes, transplant biopsy tissue, allograft rejection and injury algorithm reported as a probability score.’

3. Procedure

1. The lab analyst performs mRNA gene expression profiling using a microarray, or gene “chip,” on formalin-fixed paraffin-embedded tissue from a transplanted heart.
2. The microarray has DNA spots on a solid surface that hybridize with the specimen mRNA, providing a profile of gene expression in the tissue sample.
3. The lab analyst inputs the test results and specific patient data into a computer program that uses an algorithm to analyze the data.
4. The algorithm compares the gene expression patterns in the tissue sample to a reference library to determine the probability score of allograft rejection and injury.
5. The lab analyst reports the probability score, which helps clinicians identify the specific cause of transplant organ failure and develop a treatment plan.

4. Qualifying circumstances

CPT 0087U is used for heart transplant patients who require assessment of allograft rejection and injury. The test analyzes mRNA gene expression in transplant biopsy tissue to determine the probability score of rejection and injury. It is specifically designed for heart transplant patients and should not be used for other types of organ transplants.

5. When to use CPT code 0087U

CPT code 0087U should be used when assessing allograft rejection and injury in heart transplant patients. It is appropriate to bill this code when performing mRNA gene expression profiling using a microarray of 1283 genes in transplant biopsy tissue. This test provides valuable information for clinicians to determine the cause of transplant organ failure and develop an appropriate treatment plan.

6. Documentation requirements

To support a claim for CPT code 0087U, the following documentation is required:

• Information about the patient’s heart transplant and the need for allograft rejection and injury assessment
• Details of the mRNA gene expression profiling test performed, including the specific genes analyzed and the microarray technology used
• Date of the test and the results reported as a probability score
• Any additional information relevant to the interpretation of the test results and the patient’s condition
• Signature of the lab analyst performing the test

7. Billing guidelines

When billing for CPT code 0087U, ensure that the test is performed using the Molecular Microscope® MMDx—Heart test from Kashi Clinical Laboratories. This is a proprietary test, and only one unit of this code should be reported for a single specimen analyzed on a single date of service. Do not report this test with any other CPT code. It is important to follow the specific guidelines provided by the laboratory offering the test.

8. Historical information

CPT code 0087U is a Proprietary Laboratory Analyses (PLA) code that was added to the Current Procedural Terminology system. It is a unique code for the Molecular Microscope® MMDx—Heart test from Kashi Clinical Laboratories. There have been no updates to the code since its addition.

9. Examples

1. A heart transplant patient undergoes mRNA gene expression profiling using a microarray of 1283 genes in transplant biopsy tissue to assess the probability of allograft rejection and injury.
2. A clinician orders CPT code 0087U for a heart transplant patient with organ failure to determine the specific cause of rejection and develop an appropriate treatment plan.
3. A lab analyst performs the Molecular Microscope® MMDx—Heart test on a heart transplant biopsy tissue sample, analyzing the mRNA gene expression of 1283 genes to assess the probability of allograft rejection and injury.
4. A heart transplant patient’s biopsy tissue is analyzed using a microarray to determine the probability score of allograft rejection and injury, providing valuable information for the clinician’s decision-making process.
5. CPT code 0087U is used to assess the likelihood of allograft rejection and injury in heart transplant patients by analyzing mRNA gene expression in transplant biopsy tissue.
6. A heart transplant patient’s biopsy tissue is subjected to mRNA gene expression profiling using a microarray, allowing clinicians to determine the probability score of allograft rejection and injury.
7. The Molecular Microscope® MMDx—Heart test is performed on a heart transplant patient’s biopsy tissue, providing a probability score for allograft rejection and injury based on mRNA gene expression profiling.
8. A heart transplant patient’s biopsy tissue is analyzed using a microarray to assess the likelihood of allograft rejection and injury, aiding clinicians in developing an appropriate treatment plan.
9. CPT code 0087U is used to analyze mRNA gene expression in transplant biopsy tissue, helping clinicians determine the probability of allograft rejection and injury in heart transplant patients.
10. A heart transplant patient undergoes mRNA gene expression profiling using a microarray to assess the probability of allograft rejection and injury, providing valuable insights for the management of their condition.