How To Use CPT Code 0341U

CPT 0341U describes the fetal aneuploidy DNA sequencing comparative analysis using fetal DNA from products of conception. This article will cover the description, official description, procedure, qualifying circumstances, appropriate usage, documentation requirements, billing guidelines, historical information, and examples.

1. What is CPT Code 0341U?

CPT 0341U can be used to describe the fetal aneuploidy DNA sequencing comparative analysis. This code is used when analyzing fetal DNA from products of conception to determine if there are any abnormalities in the chromosome number, such as monosomy, trisomy, partial deletion/duplication, mosaicism, and segmental aneuploidy.

2. Official Description

The official description of CPT code 0341U is: ‘Fetal aneuploidy DNA sequencing comparative analysis, fetal DNA from products of conception, reported as normal (euploidy), monosomy, trisomy, or partial deletion/duplication, mosaicism, and segmental aneuploidy.’

3. Procedure

1. The lab analyst isolates fetal cells from a maternal blood specimen taken between eight and 22 weeks gestation.
2. The fetal DNA is then analyzed using DNA sequencing to evaluate for abnormalities in the chromosome number.
3. The analysis includes checking for aneuploidies such as Down syndrome, trisomy 13, trisomy 18, and other chromosomal abnormalities.
4. The test can also detect gene deletions/duplications larger than 1.5 million bases (Mb) and 2 Mb, respectively.
5. If present, the test may also detect mosaicism, which is when there are different genotypes in different sets of cells.

4. Qualifying circumstances

CPT 0341U is used for analyzing fetal DNA from products of conception to determine if there are any abnormalities in the chromosome number. This test is typically ordered instead of more common tests like cell-free noninvasive prenatal testing (cfNIPT) for earlier detection, fewer false positives due to maternal genotype, and higher resolution. It may also preclude the need for more invasive testing such as amniocentesis and chorionic villi sampling (CVS) that present risks to the fetus.

5. When to use CPT code 0341U

CPT code 0341U should be used when analyzing fetal DNA from products of conception to determine if there are any abnormalities in the chromosome number. This code is specifically for the Single Cell Prenatal Diagnosis (SCPD) Test from Luna Genetics Inc. It should not be reported using any other CPT code.

6. Documentation requirements

To support a claim for CPT 0341U, the documentation should include:

• Maternal blood specimen details, including the date of collection and gestational age
• Analysis of fetal DNA for aneuploidies, gene deletions/duplications, and mosaicism
• Results reported as normal (euploidy), monosomy, trisomy, partial deletion/duplication, mosaicism, and segmental aneuploidy
• Signature of the lab analyst performing the analysis

7. Billing guidelines

When billing for CPT 0341U, ensure that the test is performed by Luna Genetics Inc. and that it is the Single Cell Prenatal Diagnosis (SCPD) Test. Report one unit of this code for a single specimen analyzed on a single date of service. Some payers may also separately reimburse for specimen collection.

8. Historical information

CPT 0341U is a Proprietary Laboratory Analyses (PLA) code that was added to the CPT code set on October 1, 2022. It is specific to the Single Cell Prenatal Diagnosis (SCPD) Test from Luna Genetics Inc. There have been no updates to the code since its addition.

9. Examples

1. A maternal blood specimen taken at 12 weeks gestation is analyzed using the SCPD Test from Luna Genetics Inc. The results show normal chromosome number (euploidy).
2. A maternal blood specimen taken at 18 weeks gestation is analyzed using the SCPD Test from Luna Genetics Inc. The results show trisomy 21 (Down syndrome).
3. A maternal blood specimen taken at 20 weeks gestation is analyzed using the SCPD Test from Luna Genetics Inc. The results show partial deletion of chromosome 5.
4. A maternal blood specimen taken at 10 weeks gestation is analyzed using the SCPD Test from Luna Genetics Inc. The results show mosaicism with different genotypes in different sets of cells.
5. A maternal blood specimen taken at 16 weeks gestation is analyzed using the SCPD Test from Luna Genetics Inc. The results show segmental aneuploidy on chromosome 9.