How To Use CPT Code 0345U

CPT 0345U describes the genomic analysis panel for psychiatry, specifically for conditions such as depression, anxiety, and attention deficit hyperactivity disorder (ADHD). This article will cover the description, official details, procedure, qualifying circumstances, appropriate usage, documentation requirements, billing guidelines, historical information, and examples.

1. What is CPT Code 0345U?

CPT 0345U can be used to describe a specific genomic analysis panel for psychiatry. This code is used for variant analysis of 15 genes, including deletion/duplication analysis of the CYP2D6 gene. The test is performed using a buccal (cheek) swab specimen and provides information on possible interactions between the patient’s genes and psychotropic medications.

2. Official Description

The official description of CPT code 0345U is: ‘Psychiatry (eg, depression, anxiety, attention deficit hyperactivity disorder [ADHD]), genomic analysis panel, variant analysis of 15 genes, including deletion/duplication analysis of CYP2D6.’

3. Procedure

1. The lab analyst collects a buccal (cheek) swab specimen from the patient.
2. The gene panel of 15 genes, including deletion/duplication analysis of CYP2D6, is evaluated using the buccal swab specimen.
3. The test includes an algorithmic analysis that uses bioinformatics to evaluate each psychotropic medication for appropriate dosing and possible drug metabolism and interaction risks based on the patient’s genetic findings.
4. The test results provide a list of psychotropic medications with indications of possible interactions with the patient’s genes.

4. Qualifying circumstances

CPT 0345U is applicable for patients with psychiatric conditions such as depression, anxiety, and ADHD. The test is ordered by clinicians prior to prescribing psychotropic medications to evaluate potential value or side effects based on the patient’s genes and drug information.

5. When to use CPT code 0345U

CPT code 0345U should be used when a genomic analysis panel for psychiatry is performed, specifically for variant analysis of 15 genes, including deletion/duplication analysis of CYP2D6. This code is used to report the test for a single specimen analyzed on a single date of service.

6. Documentation requirements

To support a claim for CPT 0345U, the following documentation is required:

• Patient’s psychiatric diagnosis
• Specific genes included in the analysis panel
• Date of the test
• Results of the variant analysis, including any identified deletions or duplications
• Algorithmic analysis findings, including a list of psychotropic medications with indications of possible interactions
• Signature of the lab analyst performing the test

7. Billing guidelines

When billing for CPT 0345U, ensure that the test is performed for the appropriate genomic analysis panel for psychiatry. Report one unit of this code for a single specimen analyzed on a single date of service. Do not report this test using any other CPT code.

8. Historical information

CPT 0345U was added to the Current Procedural Terminology system on October 1, 2022. There have been no updates to the code since its addition.

9. Examples

1. A clinician orders CPT 0345U for a patient with depression to evaluate potential interactions between the patient’s genes and psychotropic medications.
2. A psychiatrist requests CPT 0345U for a patient with anxiety to assess the patient’s genetic profile and determine appropriate psychotropic medication options.
3. A pediatrician orders CPT 0345U for a child with ADHD to evaluate the potential value and side effects of psychotropic medications based on the child’s genetic findings.
4. A mental health provider requests CPT 0345U for a patient with bipolar disorder to assess the patient’s genetic profile and guide medication choices.
5. A primary care physician orders CPT 0345U for a patient with schizophrenia to evaluate potential interactions between the patient’s genes and psychotropic medications.
6. A psychiatrist requests CPT 0345U for a patient with post-traumatic stress disorder (PTSD) to assess the patient’s genetic profile and determine appropriate psychotropic medication options.
7. A clinician orders CPT 0345U for a patient with obsessive-compulsive disorder (OCD) to evaluate potential interactions between the patient’s genes and psychotropic medications.
8. A mental health provider requests CPT 0345U for a patient with borderline personality disorder to assess the patient’s genetic profile and guide medication choices.
9. A psychiatrist orders CPT 0345U for a patient with major depressive disorder to evaluate potential interactions between the patient’s genes and psychotropic medications.
10. A primary care physician requests CPT 0345U for a patient with generalized anxiety disorder to assess the patient’s genetic profile and determine appropriate psychotropic medication options.