How To Use CPT Code 81310

CPT 81310 describes the genetic analysis procedure for the NPM1 (nucleophosmin) gene, specifically analyzing exon 12 variants. This article will cover the description, procedure, qualifying circumstances, appropriate usage, documentation requirements, billing guidelines, historical information, similar codes and billing examples.

1. What is CPT Code 81310?

CPT 81310 can be used to describe the genetic analysis procedure for the NPM1 gene, focusing on the evaluation of exon 12 variants. This code is used when a lab analyst performs the technical steps involved in detecting specific changes or mutations in the NPM1 gene.

2. Official Description

The official description of CPT code 81310 is: ‘NPM1 (nucleophosmin) (eg, acute myeloid leukemia) gene analysis, exon 12 variants.’

3. Procedure

1. The lab analyst performs various technical steps, including extracting nucleic acids, amplifying the quantity of nucleic acid for analysis, and detecting the target genes using nucleic acid probes.

4. Qualifying circumstances

CPT 81310 is commonly ordered for patients with acute myeloid leukemia (AML), particularly those who do not show inherited genetic changes related to the condition. This test is specifically used to evaluate mutations in exon 12 of the NPM1 gene.

5. When to use CPT code 81310

CPT code 81310 should be used when a genetic analysis procedure is performed to detect specific changes or mutations in the NPM1 gene, specifically focusing on exon 12 variants.

6. Documentation requirements

To support a claim for CPT 81310, documentation should include:

• Patient’s diagnosis or indication for the genetic analysis
• Specific details about the technical steps performed during the procedure
• Results of the analysis, including any identified exon 12 variants
• Signature of the lab analyst performing the procedure

7. Billing guidelines

When billing for CPT 81310, ensure that the procedure involves the analysis of exon 12 variants of the NPM1 gene. It is important to follow the specific guidelines provided by the payer and accurately report the service provided.

8. Historical information

CPT 81310 was added to the Current Procedural Terminology system on January 1, 2012. There have been no updates to the code since its addition.

9. Examples

1. A lab analyst performing a genetic analysis procedure to detect exon 12 variants of the NPM1 gene in a patient with acute myeloid leukemia.
2. A geneticist analyzing the NPM1 gene for exon 12 variants in a patient with cytogenetically normal AML.
3. A hematologist ordering a genetic analysis to evaluate exon 12 mutations in the NPM1 gene for a patient with suspected AML.
4. A molecular biologist performing a genetic analysis procedure to identify exon 12 variants of the NPM1 gene in a patient with an undiagnosed hematologic disorder.
5. A pathologist analyzing the NPM1 gene for exon 12 mutations in a patient with relapsed AML.
6. A genetic counselor ordering a genetic analysis to assess exon 12 variants of the NPM1 gene in a patient with a family history of AML.
7. A hematopathologist performing a genetic analysis procedure to detect exon 12 mutations in the NPM1 gene for a patient with suspected myelodysplastic syndrome.
8. A molecular geneticist analyzing the NPM1 gene for exon 12 variants in a patient with therapy-related AML.
9. A hematologist ordering a genetic analysis to evaluate exon 12 mutations in the NPM1 gene for a patient with refractory AML.
10. A lab technician performing a genetic analysis procedure to identify exon 12 variants of the NPM1 gene in a patient with suspected myeloproliferative neoplasm.