Use CPT code 87389 for HIV screening with various immunoassay techniques to detect HIV 1 and 2 antigens and antibodies and reported as a single result.
1. What Is CPT Code 87389?
CPT 87389 covers a screening test for HIV (Human Immunodeficiency Virus). The lab analyst screens for virus antigens and antibodies to HIV 1 and 2 with an immunoassay technique (for example, EIA).
The results of this test do not show a difference between HIV antigens or antibodies.
The CPT book defines the official description of 87389 as follows: “Infectious agent antigen detection by immunoassay technique (e.g., enzyme immunoassay [EIA], enzyme-linked immunosorbent assay [ELISA], fluorescence immunoassay [FIA], immunochemiluminometric assay [IMCA]), qualitative or semiquantitative; HIV-1 antigen(s), with HIV-1 and HIV-2 antibodies, single result.”
The 87389 CPT code procedure begins when the lab analyst receives the patient’s specimen (for example, serum) before they use an immunoassay technique to detect HIV antigens and antibodies.
The lab analyst searches for the presence of HIV 1 antigens (for example, HIV p24) which are specific protein particles on the virus, and HIV 1 and 2 antibodies, which are proteins produced by the patient’s body to react to HIV 1 and 2 antigens.
The following methods could be applied during the 87389 procedure to the Human Immunodeficiency Virus (HIV);
- Immunochemiluminometric assay (IMCA);
- Fluorescence immunoassay (FIA);
- Enzyme-linked immunosorbent assay (ELISA); or
- enzyme immunoassay (EIA).
The results of this test won’t differentiate between HIV antibodies or antigens.
4. How To Use CPT 87389
CPT code 87389 is often used by clinicians as a first test to screen a patient for HIV. A positive outcome will be confirmed with other tests before the patient is diagnosed as HIV positive.
Use CPT 87389 only if the HIV1 antigens and HIV2 and 2 antibodies are yielded in a single result. You may use CPT 86701, CPT 86702, or CPT 86702 for HIV antibody tests.
Collection of the patient’s specimen has to be billed separately if the payer requires that. In that case, you may add CPT 36415 for venipuncture to the claim.
CPT code 87389 can only be billed for HIV1 and HIV2 immunoassay testing. Report CPT 87390 for HIV1 immunoassay testing and CPT 87391 for HIV2 immunoassay testing.
HIV antigen tests can be billed with CPT 87534, CPT CPT 87535, CPT CPT 87536, and CPT CPT 87537. HIV genotype analysis may be billed with CPT 87901 and CPT 87906.
Do not report CPT code 87389 for testing culture isolates. Instead, report codes from the range CPT 87140 to CPT 87158.
Modifier 59 could be added to each test (billed with CPT code 87389) if the provider tested for different species or strains of the organism.
CPT code 87389 is a CLIA-waived test.