Presumptive drug testing is described by the CPTs manual with CPT 80305, CPT 80306, or CPT 80307.
Drug classes are often assayed with a presumptive drug screening method. This is often followed by a definitive drug identification method. The methodology needed for drug identification can be determined with presumptive procedures.
CPT 80305, CPT 80306, and CPT 80307 describe the drug classes for each methodology per service date.
The presumptive drug testing codes also include sample validation procedures. For example, nitrite, specific gravity, or pH.
CPT Code 80300, CPT Code 80301, CPT Code 80302, CPT Code 80303, and CPT Code 80304 were used for Presumptive Drug Testing from 2015 until 2017 and replaced by CPT 80305, CPT 80306 and 80307 in 2017.
CPT Code 80305
CPT 80305 can be reported when a lab analyst performs a presumptive drug test (any method is allowed), so the analyst can read the results by direct optical observation.
This is done without instrument assistance with the aim of screening for any drug classes on a particular date.
CPT code 80305 is officially described by the CPTs manual and is defined as follows: “Drug test(s), presumptive, any number of drug classes, any number of devices or procedures; capable of being read by direct optical observation only (e.g., utilizing immunoassay [e.g., dipsticks, cups, cards, or cartridges]), includes sample validation when performed, per date of service.”
The 80305 CPT code procedure starts with a lab analyst performing the technical steps to test a patient’s specimen (urine or blood for example) for drug classes for the presumptive screening test.
The results from presumptive drug tests indicate a possible (but not definitive) presence of metabolites and/or drugs.
The analyst from the lab can use methods that are capable of being read by optical observation alone. This is often an immunoassay that includes cartridges, cards, cups, or dipsticks.
In the meantime, the analyst can perform a test to validate that the patient’s specimen is blood or urine with, for example, pH, creatinine, or urinalysis tests.
This test might be ordered by clinicians in case of a suspected drug overdose for a test to screen for possible drug abuse.
The drug test does provide qualitative test results. The clinician who performed the initial test might order a follow-up test to quantify the amount of drugs found in the patient’s specimen that yielded positive results on the initial test.
CPT 80305 is a CLIA-waived test and a resequenced code. You can only report this code once per date of service.
If the presumptive drug includes instrument assistance, report CPT 80306 instead of CPT 80305.
CPT Code 80306
Report CPT 80306 for procedures that include instrument(s) for determining the results of a test performed with a direct optical observation methodology.
Examples of these instruments are cards, dipsticks, or cartridges. The cartridges are inserted into an instrument to determine a test result with an optical observation methodology.
CPT code 80306 is defined by the CPTs manual and is officially described as: “Drug test(s), presumptive, any number of drug classes, any number of devices or procedures; read by instrument-assisted direct optical observation (eg, utilizing immunoassay [e.g., dipsticks, cups, cards, or cartridges]), includes sample validation when performed, per date of service.”
The 80306 CPT code procedure also starts with a lab analyst who goes through all the technical steps to test the patient’s specimen for any number of drugs.
The difference between CPT 80305 and CPT 80306 is that this procedure includes any method read by instrument-assisted direct optical observation. The rest of this procedure is similar to CPT 80305. Any method can be used by the lab analyst. This includes cartridges, cards, cups, or dipsticks.
This procedure also includes a test to check in the specimen is from the patient and if it is urine. The lab analyst can use tests like pH, creatinine, or urinalysis.
Clinicians might also use this procedure to test for drug abuse or overdose, and they can order a follow-up test to quantify the amount of drug found in the patient’s specimen.
You can only report CPT code 80306 one time per date of service. This code is resequenced.
Report CPT 80305 instead of CPT 80306 if the presumptive drug test does not include instrument assistance.
CPT 80307 can also be used for presumptive drug testing, but this procedure includes any number of procedures/devices needed for instrumented chemistry analyzers.
Examples of instrumented chemistry analyzers are;
- immunoassay (for example, RIA, KIMS, IA, FPIA, EMIT, ELISA, or EIA);
- chromatography (for example, HPLC or GC);
- mass spectrometry with or without chromatography (for example, TOF, MALDI, LDTD, LC-MS/MS, LC-MS, GC-MS/MS, GC-MS, DESI, or DART).
You can find the complete billing guide for CPT code 80307 here.
Deleted CPT Codes For Drug Testing (2017)
The following CPT codes were used for Drug Testing from 2015 until 2017. CPT Code 80300, CPT Code 80301, CPT Code 80302, CPT Code 80303 & CPT Code 80304.
CPT Code 80300 (DELETED)
Description of CPT 80300: Drug screen, any number of drug classes from Drug Class List A; any number of non-TLC devices or procedures, (eg, immunoassay) capable of being read by direct optical observation, including instrumented-assisted when performed (eg, dipsticks, cups, cards, cartridges), per date of service.
CPT Code 80301 (DELETED)
Description of CPT 80301: Drug screen, any number of drug classes from Drug Class List A; single drug class method, by instrumented test systems (eg, discrete multichannel chemistry analyzers utilizing immunoassay or enzyme assay), per date of service.
CPT Code 80302 (DELETED)
Description of CPT 80302: Drug screen, presumptive, single drug class from Drug Class List B, by immunoassay (eg,ELISA) or non-TLC chromatography without mass spectrometry (eg, GC, HPLC), each procedure
CPT Code 80303 (DELETED)
Description of CPT 80303: Drug screen, any number of drug classes, presumptive, single or multiple drug class method; thin layer chromatography procedures(s) (TLC) (eg, acid, neutral, alkaloid plate), per date of service
CPT Code 80304 (DELETED)
Description of CPT 80304: Drug screen, any number of drug classes, presumptive, single or multiple drug class method; not otherwise specified presumptive procedure (eg, TOF, MALDI, LDTD, DESI, DART), each procedure