Coding Ahead
CasePilot
Medical Coding Assistant
CaseConsultant
Instant Email Coding Consultant
Case2Code
Search and Code Lookup Tool
CareerCenter
Medical Coding Job Board
Log in Register free account

Need help choosing the right code?

Ask CasePilot about procedures, modifiers, bundling, and coding guidance.

Try CasePilot

Official Description

Endoscopic retrograde cholangiopancreatography (ERCP), with optical endomicroscopy (List separately in addition to code for primary procedure)

© Copyright 2026 American Medical Association. All rights reserved.

Common Language Description

Endoscopic retrograde cholangiopancreatography (ERCP) with optical endomicroscopy is a specialized procedure that combines traditional ERCP techniques with advanced imaging capabilities. ERCP is a minimally invasive procedure that involves the use of an endoscope, which is a flexible tube equipped with a camera and light source, to visualize the bile and pancreatic ducts. The procedure begins with the endoscope being passed through the esophagus and stomach, reaching the duodenum, where the pancreatic duct and common bile duct converge at a location known as the ampulla of Vater. At this juncture, a smaller catheter is introduced through the endoscope to cannulate the ampulla, allowing for the injection of contrast dye into the ducts. This contrast dye is crucial as it enables the visualization of the biliary tract, gallbladder, and pancreas through X-ray imaging, which is captured immediately after the dye is administered. The integration of optical endomicroscopy enhances the ERCP procedure by providing in vivo visualization of the mucosal tissue within the biliary and pancreatic ducts. This advanced imaging technique allows for the examination of the tissue at a microscopic level, revealing histological details that are critical for diagnosing various pathophysiological conditions. During the procedure, a miniaturized endomicroscope, which may be integrated into the endoscope or inserted through it, utilizes a blue laser light to scan the mucosal layers from the surface down to the deepest levels. This capability not only aids in identifying areas of concern but also facilitates the collection of targeted biopsies from specific regions exhibiting microscopic changes, rather than relying on random sampling. The immediate histological information obtained through optical endomicroscopy can significantly influence treatment decisions, making this procedure a valuable tool in the management of biliary and pancreatic disorders.

© Copyright 2026 Coding Ahead. All rights reserved.

1. Indications

The procedure of endoscopic retrograde cholangiopancreatography (ERCP) with optical endomicroscopy is indicated for various conditions affecting the biliary and pancreatic systems. These indications include:

  • Obstructive jaundice - This condition occurs when there is a blockage in the bile duct, leading to the accumulation of bile and subsequent jaundice.
  • Cholelithiasis - The presence of gallstones in the gallbladder or bile ducts can necessitate ERCP to remove the stones and relieve obstruction.
  • Pancreatitis - Inflammation of the pancreas may require ERCP to identify and treat underlying causes, such as bile duct obstruction.
  • Biliary strictures - Narrowing of the bile ducts can lead to complications, and ERCP can be used to diagnose and potentially treat these strictures.
  • Suspected malignancies - ERCP with optical endomicroscopy can assist in the evaluation of suspected tumors in the biliary or pancreatic regions.

2. Procedure

The procedure of endoscopic retrograde cholangiopancreatography (ERCP) with optical endomicroscopy involves several critical steps to ensure successful visualization and intervention within the biliary and pancreatic ducts. The following procedural steps are performed:

  • Step 1: Patient Preparation - Prior to the procedure, the patient is typically advised to fast for a certain period to ensure an empty stomach. Sedation is administered to enhance comfort during the procedure.
  • Step 2: Endoscope Insertion - The physician carefully inserts the endoscope through the patient's mouth, guiding it down the esophagus and into the stomach, and finally into the duodenum, where the ampulla of Vater is located.
  • Step 3: Cannulation of the Ampulla - A smaller catheter is introduced through the endoscope to cannulate the ampulla of Vater. This step is crucial for accessing the bile and pancreatic ducts.
  • Step 4: Contrast Injection - Once the ampulla is cannulated, contrast dye is injected into the ducts. This allows for the visualization of the biliary tract, gallbladder, and pancreas through X-ray imaging.
  • Step 5: Optical Endomicroscopy - Following the contrast injection, optical endomicroscopy is performed using a miniaturized endomicroscope. This device scans the biliary ductal mucosa with a blue laser light, providing detailed images of the mucosal layers.
  • Step 6: Biopsy Collection - If areas of concern are identified during the optical endomicroscopy, targeted biopsies can be obtained from these specific regions, allowing for immediate histological analysis.
  • Step 7: Conclusion of the Procedure - After the necessary interventions and imaging are completed, the endoscope is carefully withdrawn, and the patient is monitored as they recover from sedation.

3. Post-Procedure

After the completion of the endoscopic retrograde cholangiopancreatography (ERCP) with optical endomicroscopy, patients are typically monitored in a recovery area until the effects of sedation wear off. It is common for patients to experience some mild discomfort, such as a sore throat or abdominal cramping, which usually resolves quickly. The physician may provide specific post-procedure instructions, including dietary recommendations and signs of potential complications to watch for, such as fever, severe abdominal pain, or jaundice. Follow-up appointments may be scheduled to discuss biopsy results and any further treatment options if necessary. Overall, the recovery period is generally short, with many patients able to resume normal activities within a day or two, depending on individual circumstances and the complexity of the procedure performed.

Short Descr ERCP W/OPTICAL ENDOMICROSCPY
Medium Descr ERCP WITH OPTICAL ENDOMICROSCOPY ADD ON
Long Descr Endoscopic retrograde cholangiopancreatography (ERCP), with optical endomicroscopy (List separately in addition to code for primary procedure)
Status Code Carriers Price the Code
Global Days XXX - Global Concept Does Not Apply
PC/TC Indicator (26, TC) 0 - Physician Service Code
Multiple Procedures (51) 0 - No payment adjustment rules for multiple procedures apply.
Bilateral Surgery (50) 0 - 150% payment adjustment for bilateral procedures does NOT apply.
Physician Supervisions 09 - Concept does not apply.
Assistant Surgeon (80, 82) 0 - Payment restriction for assistants at surgery applies to this procedure...
Co-Surgeons (62) 0 - Co-surgeons not permitted for this procedure.
Team Surgery (66) 0 - Team surgeons not permitted for this procedure.
Diagnostic Imaging Family 99 - Concept Does Not Apply
APC Status Indicator Items and Services Packaged into APC Rates
ASC Payment Indicator Packaged service/item; no separate payment made.
Berenson-Eggers TOS (BETOS) P8I - Endoscopy - other
MUE 1

This is an add-on code that must be used in conjunction with one of these primary codes.

43260 MPFS Status: Active Code APC J1 ASC A2 Physician Quality Reporting PUB 100 CPT Assistant Article Illustration for Code Endoscopic retrograde cholangiopancreatography (ERCP); diagnostic, including collection of specimen(s) by brushing or washing, when performed (separate procedure)
43261 MPFS Status: Active Code APC J1 ASC A2 Physician Quality Reporting CPT Assistant Article Illustration for Code Endoscopic retrograde cholangiopancreatography (ERCP); with biopsy, single or multiple
43262 MPFS Status: Active Code APC J1 ASC A2 Physician Quality Reporting PUB 100 CPT Assistant Article Illustration for Code Endoscopic retrograde cholangiopancreatography (ERCP); with sphincterotomy/papillotomy
43263 MPFS Status: Active Code APC J1 ASC A2 Physician Quality Reporting PUB 100 CPT Assistant Article Illustration for Code Endoscopic retrograde cholangiopancreatography (ERCP); with pressure measurement of sphincter of Oddi
43264 MPFS Status: Active Code APC J1 ASC A2 Physician Quality Reporting PUB 100 CPT Assistant Article Illustration for Code Endoscopic retrograde cholangiopancreatography (ERCP); with removal of calculi/debris from biliary/pancreatic duct(s)
43265 MPFS Status: Active Code APC J1 ASC A2 Physician Quality Reporting PUB 100 CPT Assistant Article Illustration for Code Endoscopic retrograde cholangiopancreatography (ERCP); with destruction of calculi, any method (eg, mechanical, electrohydraulic, lithotripsy)
43274 Resequenced Code MPFS Status: Active Code APC J1 ASC J8 Endoscopic retrograde cholangiopancreatography (ERCP); with placement of endoscopic stent into biliary or pancreatic duct, including pre- and post-dilation and guide wire passage, when performed, including sphincterotomy, when performed, each stent
43275 Resequenced Code MPFS Status: Active Code APC J1 ASC G2 Endoscopic retrograde cholangiopancreatography (ERCP); with removal of foreign body(s) or stent(s) from biliary/pancreatic duct(s)
43276 Resequenced Code MPFS Status: Active Code APC J1 ASC J8 Endoscopic retrograde cholangiopancreatography (ERCP); with removal and exchange of stent(s), biliary or pancreatic duct, including pre- and post-dilation and guide wire passage, when performed, including sphincterotomy, when performed, each stent exchanged
43277 Resequenced Code MPFS Status: Active Code APC J1 ASC G2 Endoscopic retrograde cholangiopancreatography (ERCP); with trans-endoscopic balloon dilation of biliary/pancreatic duct(s) or of ampulla (sphincteroplasty), including sphincterotomy, when performed, each duct
43278 Resequenced Code MPFS Status: Active Code APC J1 ASC G2 Endoscopic retrograde cholangiopancreatography (ERCP); with ablation of tumor(s), polyp(s), or other lesion(s), including pre- and post-dilation and guide wire passage, when performed
GC This service has been performed in part by a resident under the direction of a teaching physician
Date
Action
Notes
2017-01-01 Changed Moderate (Conscious) Sedation flag removed. See new Moderate Sedation category.
2016-01-01 Added Added
Code
Description
CasePilot

Get instant expert-level medical coding assistance.

Ask about:
CPT Codes Guidelines Modifiers Crosswalks NCCI Edits Compliance Medicare Coverage
Example: "What is CPT code 99213?" or "Guidelines for E/M services"