endometrial biopsy cpt code

Endometrial Biopsy CPT Code (2022) Description, Guidelines, Reimbursement, Modifiers & Examples

Endometrial Biopsy CPT code(s) are 58100-58170. Following CPT, excision procedures on the corpus uteri are coded 58100-58146 by the American Medical Association. An endometrial biopsy is a procedure in which a physician obtains a tissue sample from the uterine lining without opening the cervix. If the practitioner chooses, they may also do an endocervical biopsy on the patient.

Endometrial Biopsy CPT Code Description

The health professional can use code 57454 to report a cervical biopsy and endocervical procedure for the patient. The service codes 57455 and 57456 do not cover a colposcopy with a biopsy since it is not considered medically necessary. 

The procedure includes a colposcopy with endocervical curettage. Under some circumstances may, more than one of these codes may be billed simultaneously under some circumstances. 57500 is a prefix for the code 58100, which contains a variety of additional regulations. It is not possible to bill both 57500 and 58100 simultaneously.

cpt code for endometrial biopsy

Because of cervical stenosis, a post-menopausal woman may not be able to have an office endometrial biopsy. “Cervical dilatation” is not required for the endometrial biopsy billed with CPT 58100.

In post-menopausal women, cervical stenosis can make office endometrial biopsy harder. Following the endometrial biopsy code, “without cervical dilatation” (58100). 

Dilation and curettage are two surgical procedures performed in conjunction with one another, like with any other system, a CPT code. The number 58120 is associated with a 10-day global period. If you dilute your patient’s cervix, you should explain why, like cervical stenosis and post-menopausal bleeding. 

cpt code endometrial biopsy

A menstruation pad should be given to the patient because there is a good chance of bleeding. She is given ibuprofen or naproxen for cramps and pain if there are no contraindications. If patients have substantial discomfort, extensive bleeding, or signs or symptoms of infection (such as fever or abnormal vaginal discharge), they should be rushed to the hospital immediately for treatment.

Cervical dilatation and endometrial biopsy are two codes. As part of the colposcopy, the patient had samples of her endometrium taken. 

The health physician used an instrument to grab the cervix and pull it down during this exam. After putting the device in her endocervical canal, they will move it through her uterus.

endometrial biopsy cpt code 2021

Detecting ovarian cancer, which has the sixth-highest mortality rate of all female cancers, requires a biopsy of the ovary itself. The ovary can be biopsied in two ways: unilaterally or bilaterally. The procedure code for an ovarian biopsy is 58900. At this point, most insurance companies will treat the biopsy as part of a more extensive operation, but some may pay 58900 for it on its own. 

Writing proof and modifier -22 (Unusual procedural services) may help achieve an increased reimbursement if the biopsy involved a significant amount of effort. There are several common ovarian tumors, such as malignant neoplasms (183.0), benign tumors, tumors with strange behavior, polycystic ovaries, ovarian endometriosis, ovarian follicular cysts, and other undefined ovarian cysts.

The anesthesia-assisted biopsy procedure in 58558 is part of a more extensive procedure. Intraoperative biopsies are taken during hysteroscopic surgery and can be analyzed. At the same time, the patient is still in the operating room. Surgeons may do surgery to remove cancerous tissue or cells or even perform a hysterectomy if a biopsy confirms the diagnosis.


An endometrial biopsy with CPT code 58100 can justify a variety of additional ICD 9 diagnoses, including the malignant tumor of the body of the corpus uteri, a submucous leiomyoma, hypertrophy of the labia, and an irregular menstrual cycle. 

To support 58558, the diagnostic codes for a malignant tumor of the isthmus, benign neoplasm of the corpus uterus, carcinoma in situ of the cervix uteri, and uterine neoplasm of undetermined behavior are all applicable.

A physician performed a cervical tumor biopsy with or without colposcopy and cervical mucosa. The process involves using speculums and biopsy forceps to remove tissue or a lesion from within the cervix for biopsy procedures without using a colposcope. Samples from the cervix, as well as from the endocervical canal, are then taken by the doctor, if necessary.

Surgeons perform an Ovarian Biopsy. In a doctor’s office, the procedure can perform. If the biopsy confirms that the tumor is cancerous, the patient will undergo surgery to remove it. If pathology shows venom, the surgeon can continue the operation and remove one or both ovaries if cancer has spread.

His ovaries biopsy code is 58900 for single or double ovarian biopsies [different procedures]. At this point, most insurance companies will see the biopsy as part of a more extensive procedure, but some may cover 58900 on their own.

To get paid more for a biopsy, a combination of modifier -22 with unusual procedural services and written documentation may be helpful. It is possible to do an endometrial biopsy (biopsy) with or without an endocervical biopsy (biopsy) without dilating the cervical canal.

Codes 58570-Because it is part of a surgical procedure, cystoscopy is not reportable as an independent procedure. To do a colonoscopy, use 58110 in addition to the primary operation. However, even if an incision takes the specimen, the adnexa is still detachable during robotic surgery. 

Techniques to “check” one’s work are considered an integral part of the process. Patients diagnosed with hematuria can use an ICD code to show that the service is medically necessary.

The most commonly reported diagnoses include malignant ovarian tumors, benign and uncertain behavior, polycystic, endometriosis, unspecified cysts of the corpus luteum, unidentified ovarian follicular cysts, and other ovarian cysts.

Endometrial Biopsy CPT Code Billing Guidelines

According to the code, endometrial biopsy (58100) will be performed “without cervical dilation,” the code. A separate visit is necessary when reporting a procedure on the same day. Documentation of supplementary services is required because all methods include some patient evaluation.

 However, this does not mean that they need to take up a large amount of space. Adding a name to the method section in place of a room can help differentiate services’ codes and signify a distinct piece of work and reimbursement. E/M service may or may not qualify as a “substantial, separately identifiable” effort based on the amount provided. 

For example, the 58100 (established patient E/M service signifying problem-focused history and exam and transparent medical decision-making) has not necessarily implied an extensive visit. At the very least, you should document some level of history-taking, examination, medical decision-making, and time spent.

Endometrial Biopsy CPT Code Modifiers

Using CPT code modifier 53, you can indicate the end of a service. Modifier 53 only covers professional medical assistance, not ASC procedures. CPTs that describe diagnostic or surgical procedures that the provider no longer provides should use this code. 

If you’re only looking for restricted services, modifier 53 is similar to modifier 52, but they’re not the same thing. Changes like this can be perplexing, and submitting an improper application could lead to payment reductions or denials of your claim.

Discontinued service codes for Modifier 53 are as specific as they come. It may be essential to state that a surgical or diagnostic therapy was started but interrupted due to extenuating circumstances or jeopardizing the patient’s well-being. Modifier’ 53′ can be applied to the physician’s code to mark this event for the stopped procedure.”

You will need to figure out why the provider decided to stop the procedure after it had already begun to apply modifier 53. If you’re going to use 53, make sure you’ve already administered surgical prep and anesthesia, signaling that the procedure has started.

As a result, modifier 53 is practically a forgotten one. Many individuals have forgotten or never learned how to apply it effectively. The word “extenuating circumstances” does not have a clear definition, leaving it up to interpretation and ineffective.

 If practices do not use Modifier 53, they won’t get paid for some effort, which is disappointing. As soon as the physician completes an operation, the provider can use modifier 53 to bill for it in its entirety.

The modifier for CPT Code for Endometrial Biopsy is 53


The endometrial biopsy service is often excluded from reimbursement because it was “bundled” into the surgery. All work done on patients covered by these plans requires a separate appointment to obtain a refund for the therapy. Healthcare procedures cannot delay the process due to medical reasons, and both services have completed their work; use CPT 58100 and the procedure code with the appropriate diagnoses and modifier 53. 


The following are examples of when Endometrial Biopsy CPT code(s) may be used.

Example 1

The procedure started with a patient examined in an oncology clinic to treat menorrhagia who had had an endometrial biopsy. The health professional prevented the patients from doing so due to the risk of uterine perforation by health professionals.

Accordingly, the doctor would bill 58100-53 to demonstrate that the biopsy started for the patient due to the risk of jeopardizing the patient’s health.

Example 2

Before beginning surgery, a surgeon anesthetizes a patient. However, the surgeon cannot do the procedure due to the doctor’s self-inflicted wound. It is possible to utilize Modifier 53 to identify an extenuating circumstance that impeded the completion of the course. 

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